The human motor cortex comprises a microcircuit of five interconnected layers with different
cell types. In this Review, we use a layer-specific and cell-specific approach to integrate …

The motor system has been intensively studied using the emerging neuroimaging
technologies over the last twenty years. These include early applications of positron …

Motor neuron disease can be viewed as an umbrella term describing a heterogeneous
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …

See King et al.(doi: 10.1093/aww348) for a scientific commentary on this article. Detailed
mapping of clinical dysfunctions to the cerebellar lobules in disease populations is …

Amyotrophic lateral sclerosis is a relentlessly progressive multi-system condition. The
clinical picture is dominated by upper and lower motor neuron degeneration, but extra-motor …

Systematic spatial variation in micro-architecture is observed across the cortex. These micro-
architectural gradients are reflected in neural activity, which can be captured by …

Microglia dynamically interact with neurons influencing the development, structure, and
function of neuronal networks. Recent studies suggest microglia may also influence …

Motor neurons are a remarkably powerful cell type in the central nervous system. They
innervate and control the contraction of virtually every muscle in the body and their …

Cortical networks are characterized by the origin, destination, and reciprocity of their
connections, as well as by the diameter, conduction velocity, and synaptic efficacy of their …

Spinal motor neurons have been implicated in the loss of motor function that occurs with
advancing age. However, the cellular and molecular mechanisms that impair the function of …