The understanding of pulmonary arterial hypertension (PAH) was turned on its head just
over 20 years ago with the recognition that there were families with a specific genetic …

Pulmonary arterial hypertension (PAH) is a highly heterogeneous disorder with a complex,
multifactorial aetiology. PAH is characterized by a sustained elevation of mean pulmonary …

Mutations in the bone morphogenetic protein type II receptor (BMPR-II) gene (BMPR2) have
been recognized to cause heritable PAH (HPAH). Recent studies focused on novel BMPR2 …

Background Hereditary pulmonary arterial hypertension (HPAH) can be caused by
autosomal dominant inherited mutations of TGF-β genes, such as the bone morphogenetic …

Familial pulmonary arterial hypertension (FPAH) was described 60 years ago, but real
progress in understanding its origins and pathogenesis is just beginning. Germline …

Background A genetic predisposition can lead to the rare disease pulmonary arterial
hypertension (PAH). Most mutations have been identified in the gene BMPR2 in heritable …

Pulmonary arterial hypertension (PAH) is an uncommon disorder. PAH can be idiopathic,
associated with other conditions or clustered in families. Indeed, at least 6% of individuals …

Pulmonary arterial hypertension (PAH) is an uncommon disorder of the pulmonary
vasculature characterized by remodeling of the smallest pulmonary arteries, leading to a …

Pulmonary arterial hypertension (PAH) occurs as an idiopathic disease (formerly called
primary pulmonary hypertension) and as a consequence of other illnesses. These illnesses …

Pulmonary arterial hypertension (PAH) is an often fatal disorder resulting from several
causes including heterogeneous genetic defects. While mutations in the bone …