Thyroid hormones are essential for normal development and metabolism. Their synthesis
requires transport of iodide into thyroid follicles. The mechanisms involving the apical efflux …

Pendred syndrome is an autosomal recessive disorder defined by sensorineural deafness,
goiter and a partial organification defect of iodide. It is caused by biallelic mutations in the …

Pendred syndrome is an autosomal recessive disorder characterized by sensorineural
hearing impairment, presence of goiter, and a partial defect in iodide organification, which …

Background: Iodide uptake at the basolateral membrane and iodide efflux at the apical
membrane of thyrocytes, essential steps in the biosynthesis of thyroid hormone, are …

In the thyroid, the transport of iodide from the extracellular space to the follicular lumen
requires two steps: the transport in the cell at the basal side and in the lumen at the apical …

The Pendred syndrome gene encodes a 780-amino acid putative transmembrane protein
(pendrin) that is expressed in the apical membrane of thyroid follicular cells. Although …

Pendred syndrome is an autosomal recessive disorder characterized by congenital
deafness and thyroid goiter. The thyroid disease typically develops around puberty and is …

Thyroid hormones are essential for normal development and metabolism. Thyroid hormone
biosynthesis requires iodide uptake into the thyrocytes and efflux into the follicular lumen …

Pendred syndrome (PDS) is an autosomal recessive disorder characterized by deafness
and goiter. Phenotypic heterogeneity is observed in affected individuals, and thyroid …

Adequate iodide supply and metabolism are essential for thyroid hormones synthesis. In
thyrocytes, iodide uptake is mediated by the sodium-iodide symporter, but several proteins …