Predictive reward-prediction errors of climbing fiber inputs integrate modular reinforcement learning with supervised learning

H Hoang, S Tsutsumi, M Matsuzaki, M Kano, K Toyama… - bioRxiv, 2023 - biorxiv.org
Although the cerebellum is typically linked to supervised learning algorithms, it also exhibits
extensive connections to reward processing. In this study, we investigated the cerebellum's …

[PDF][PDF] Negative reward-prediction errors of climbing fiber inputs for cerebellar reinforcement learning algorithm

H Hoang - 2023 - researchgate.net
Although the cerebellum is widely associated with supervised learning algorithm, abundant
reward-related representations were found in the cerebellum. We ask the question whether …

Classical conditioning drives learned reward prediction signals in climbing fibers across the lateral cerebellum

W Heffley, C Hull - elife, 2019 - elifesciences.org
Classical models of cerebellar learning posit that climbing fibers operate according to a
supervised learning rule to instruct changes in motor output by signaling the occurrence of …

Evidence for reinforcement learning signals in the climbing fiber pathway expands the possible repertoire of cerebellar learning rules

W Heffley II - 2019 - search.proquest.com
Classical models of cerebellar learning posit that climbing fibers operate according to a
supervised learning rule to instruct changes in motor output by signaling the occurrence of …

Dynamic organization of cerebellar climbing fiber response and synchrony in multiple functional components reduces dimensions for reinforcement learning

H Hoang, S Tsutsumi, M Matsuzaki, M Kano, M Kawato… - Elife, 2023 - elifesciences.org
Cerebellar climbing fibers convey diverse signals, but how they are organized in the
compartmental structure of the cerebellar cortex during learning remains largely unclear. We …

Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions

W Heffley, EY Song, Z Xu, BN Taylor, MA Hughes… - Nature …, 2018 - nature.com
The prevailing model of cerebellar learning states that climbing fibers (CFs) are both driven
by, and serve to correct, erroneous motor output. However, this model is grounded largely in …

Dynamic organization of cerebellar climbing fiber response and synchrony in multiple functional modules reduces dimensions for reinforcement learning

H Hoang, S Tsutsumi, M Matsuzaki, M Kano, M Kawato… - biorxiv, 2022 - biorxiv.org
Daynamic functional organization by synchronization is theorized to be essential for
dimension reduction of the cerebellar learning space. We analyzed a large amount of …

Complex spikes encode reward expectation signals during visuomotor association learning

N Sendhilnathan, A Ipata, ME Goldberg - BioRxiv, 2019 - biorxiv.org
Climbing fiber input to Purkinje cells has been thought to instruct learning related changes in
simple spikes and cause behavioral changes through an error-based learning mechanism …

The mid-lateral cerebellum is necessary for reinforcement learning

N Sendhilnathan, ME Goldberg - BioRxiv, 2020 - biorxiv.org
The cerebellum has long been considered crucial for supervised motor learning and its
optimization-. However, new evidence has also implicated the cerebellum in reward based …

Complex spike firing adapts to saliency of inputs and engages readiness to act

L Bina, V Romano, TM Hoogland, LWJ Bosman… - bioRxiv, 2020 - biorxiv.org
The cerebellum is involved in cognition next to motor coordination. During complex tasks,
climbing fiber input to the cerebellum can deliver seemingly opposite signals, covering both …