Critical-sized bone defects often lead to non-union and full-thickness defects of the
calvarium specifically still present reconstructive challenges. In this study, we show that …

Bone regeneration, following fracture, relies on autologous and allogenic bone grafts.
However, majority of fracture population consists of older individuals with poor quality bone …

The methodology for the repair of critical-sized or non-union bone lesions has unpredictable
efficacy due in part to our incomplete knowledge of bone repair and the biocompatibility of …

Human tissue repair deficiencies can be supplemented through strategies to isolate, expand
in vitro, and reimplant regenerative cells that supplant damaged cells or stimulate …

A bstract Restoration of extensive bone loss and defects remain as an unfulfilled challenge
in modern medicine. Given the critical contributions to bone homeostasis and diseases …

Bone marrow stromal cells (BMSCs) are versatile mesenchymal cell populations
underpinning the major functions of the skeleton, a majority of which adjoin sinusoidal blood …

Multipotent stromal cells are considered attractive sources for cell therapy and tissue
engineering. Despite numerous experimental and clinical studies, broad application of …

Mesenchymal stem cells (MSCs) are multipotent cells capable of proliferating and
differentiating into several lineages. In regenerative medicine, their potential as a resource …

Approximately 10% of fractures will not heal without intervention. Current treatments can be
marginally effective, costly, and some have adverse effects. A safe and manufacturable …

Recently, extracellular matrix-based tissue-engineered bone is a promising approach to
repairing bone defects, and the seed cells are mostly mesenchymal stem cells. However …