Atherosclerosis is an inflammatory disease of the artery walls and involves immune cells
such as macrophages. Olfactory receptors (OLFRs) are G protein–coupled chemoreceptors …

Olfactory receptors (ORs) that bind odorous ligands are the largest family of G-protein-
coupled receptors. In the olfactory epithelium, approximately 400 and 1,100 members are …

ORs are ectopically expressed in non-chemosensory tissues including muscle, kidney, and
keratinocytes; however, their physiological roles are largely unknown. We found that human …

The sense of smell allows chemicals to be perceived as diverse scents. We used single-
neuron RNA sequencing to explore the developmental mechanisms that shape this ability …

The carotid body is essential for the adaptation of mammals to environmental or pathological
conditions that result in hypoxaemia. In response to hypoxia, neuron-like oxygen-sensitive …

Background Olfaction is a versatile sensory mechanism for detecting thousands of volatile
odorants. Although molecular basis of odorant signaling is relatively well understood …

Olfactory receptors are G protein-coupled receptors that mediate olfactory chemosensation
and serve as chemosensors in other tissues. We find that Olfr78, an olfactory receptor …

Abstract Activation of the 5-lipoxygenase (5-LO) pathway leads to the biosynthesis of
proinflammatory leukotriene lipid mediators. Genetic studies have associated 5-LO and its …

INTRODUCTION The innate immune system uses a variety of sensor proteins to detect
infections and injuries. The nucleotide-binding oligomerization domain, leucine-rich repeat …

INTRODUCTION The inflammasomes and the complement system are traditionally viewed
as quintessential components of innate immunity required for the detection and elimination …