Analysis of the human adult urinary metabolome variations with age, body mass index, and gender by implementing a comprehensive workflow for univariate and …

EA Thévenot, A Roux, Y Xu, E Ezan… - Journal of proteome …, 2015 - ACS Publications
Urine metabolomics is widely used for biomarker research in the fields of medicine and
toxicology. As a consequence, characterization of the variations of the urine metabolome …

[HTML][HTML] The human urine metabolome

S Bouatra, F Aziat, R Mandal, AC Guo, MR Wilson… - PloS one, 2013 - journals.plos.org
Urine has long been a “favored” biofluid among metabolomics researchers. It is sterile, easy-
to-obtain in large volumes, largely free from interfering proteins or lipids and chemically …

Global metabolic profiling analysis on human urine by UPLC–TOFMS: Issues and method validation in nutritional metabolomics

PA Guy, I Tavazzi, SJ Bruce, Z Ramadan… - … of Chromatography B, 2008 - Elsevier
Optimisation and method validation was assessed here for metabolic profiling analysis of
urine samples using UPLC–TOFMS. A longer run time of 31min revealed greater …

Annotation of the human adult urinary metabolome and metabolite identification using ultra high performance liquid chromatography coupled to a linear quadrupole …

A Roux, Y Xu, JF Heilier, MF Olivier, E Ezan… - Analytical …, 2012 - ACS Publications
Metabolic profiles of biofluids obtained by atmospheric pressure ionization mass
spectrometry-based technologies contain hundreds to thousands of features, most of them …

Mass spectrometric based approaches in urine metabolomics and biomarker discovery

MM Khamis, DJ Adamko… - Mass spectrometry …, 2017 - Wiley Online Library
Urine metabolomics has recently emerged as a prominent field for the discovery of non‐
invasive biomarkers that can detect subtle metabolic discrepancies in response to a specific …

Mealtime, temporal, and daily variability of the human urinary and plasma metabolomes in a tightly controlled environment

K Kim, C Mall, SL Taylor, S Hitchcock, C Zhang… - PloS one, 2014 - journals.plos.org
While metabolomics has tremendous potential for diagnostic biomarker and therapeutic
target discovery, its utility may be diminished by the variability that occurs due to …

Standardization of factors that influence human urine metabolomics

LG Rasmussen, F Savorani, TM Larsen, LO Dragsted… - Metabolomics, 2011 - Springer
In nutritional metabolomics a large inter-and intra-subject variability exists, and thus, it
becomes important to limit the variance introduced by external factors. In a composite …

Urine metabolomics

A Zhang, H Sun, X Wu, X Wang - Clinica Chimica Acta, 2012 - Elsevier
Metabolomics is a powerful technique for the discovery of novel biomarkers and elucidation
of biochemical pathways to improve diagnosis, prognosis and therapy. An advantage of this …

Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles

CM Slupsky, KN Rankin, J Wagner, H Fu… - Analytical …, 2007 - ACS Publications
Metabolomics may have the capacity to revolutionize disease diagnosis through the
identification of scores of metabolites that vary during environmental, pathogenic, or …

Optimized Analytical Procedures for the Untargeted Metabolomic Profiling of Human Urine and Plasma by Combining Hydrophilic Interaction (HILIC) and Reverse …

K Contrepois, L Jiang, M Snyder - Molecular & Cellular Proteomics, 2015 - ASBMB
Profiling of body fluids is crucial for monitoring and discovering metabolic markers of health
and disease and for providing insights into human physiology. Since human urine and …