The distinguishing pathogenic features of neurodegenerative diseases include
mitochondrial dysfunction and derived reactive oxygen species generation. The neural …

Neurodegenerative diseases comprise a wide spectrum of pathologies characterized by
progressive loss of neuronal functions and structures. Despite having different genetic …

The most common neurodegenerative diseases include Alzheimer's disease, Parkinson's
disease and stroke; they are devastating clinical problems which lack effective treatments …

Alzheimer's disease (AD) is a major cause of dementia in older adults and is fast becoming
a major societal and economic burden due to an increase in life expectancy. Age seems to …

The intricate physiology of many Central Nervous System (CNS) disorders points towards
oxidative damages of neurons. Various studies have established that oxidative stress is a …

Mitochondrial dysfunction and oxidative stress are two interdependent and reinforcing
damage mechanisms that play a central role in brain aging. Oxidative stress initiated and …

Neurodegenerative diseases are intricate in nature because of the involvement of the
multiple pathophysiological events including mitochondrial dysfunction, neuroinflammation …

The neurodegenerative process is characterized by the progressive ultrastructural
alterations of selected classes of neurons accompanied by imbalanced cellular …

Free radical or oxidative stress may be a fundamental mechanism underlying several
human neurologic diseases. Therapy using free radical scavengers (antioxidants) has the …

Free radicals are common outcome of normal aerobic cellular metabolism. In-built
antioxidant system of body plays its decisive role in prevention of any loss due to free …