Cryptococcus neoformans (Cn) is an opportunistic fungal microorganism that causes life-
threatening meningoencephalitis. During the infection, the microbial population is …

Cryptococcus neoformans (Cn) is an opportunistic fungal microorganism that causes life-
threatening meningoencephalitis. During the infection, the microbial population is …

Does cell age matter in virulence? The emergence of persister cells during chronic
infections is critical for persistence of infection, but little is known how this occurs. Here, we …

Metabolically quiescent pathogens can persist in a viable non-replicating state for months or
even years. For certain infectious diseases, such as tuberculosis, cryptococcosis …

Cryptococcus gattii is an encapsulated fungus capable of causing fatal disease in
immunocompetent humans and animals. As current antifungal therapies are few and limited …

Cryptococcus neoformans is a facultative intracellular fungal pathogen. Ten-generation-old
(10GEN) C. neoformans cells are more resistant to phagocytosis and killing by …

Immunosenescence refers to the age-related progressive decline of immune function
contributing to the increased susceptibility to infectious diseases in older people …

Cryptococcus neoformans causes meningoencephalitis in immunocompromised individuals,
which is treated with fluconazole (FLC) monotherapy when resources are limited. This can …

Cryptococcus neoformans causes meningoencephalitis in immunocompromised individuals,
which is treated with fluconazole (FLC) monotherapy when resources are limited. This can …

Antibiotic tolerance is the ability of a susceptible population to survive high doses of cidal
drugs and has been shown to compromise therapeutic outcomes in bacterial infections. In …