Asthma is a common chronic inflammatory condition which affects over 300 million people
worldwide. Thickening of the subepithelial layer is a key feature of asthmatic airways and the …

Asthma is a chronic heterogeneous respiratory condition that is mainly associated with
sensitivity to airborne agents such as pollen, dust mite products and fungi. Key pathological …

Background Asthma is a chronic inflammatory condition of the airways and patients
sensitized to airborne fungi such as Aspergillus fumigatus have more severe asthma …

Introduction 3. Airway Remodeling in Allergic Asthma 4. Airway Wall Remodeling in Patients
with ABPA 5. Interaction of Airway Epithelium with Aspergillus 6. Aspergillus Proteolytic …

For decades, fungi have been recognized as associated with asthma and other reactive
airway diseases. In contrast to type I-mediated allergies caused by pollen, fungi cause a …

Fungal sensitisation and Allergic Bronchopulmonary Aspergillosis (ABPA) are seen more
commonly in severe asthma. Asthmatics with ABPA/SAFS have differing disease trajectories …

Although fungi are pervasive in many environments, few cause disease in humans. Of these,
Aspergillus fumigatus is particularly well suited to be a pathogen of the human lung. Its …

Aspergillus fumigatus is a filamentous fungus and the main pathogen responsible for the
often fatal respiratory condition, aspergillosis. Airway epithelial cells (AECs) are likely to be …

Background: A. fumigatus is an important human pathogen with disease manifestations
being entirely dependent on the underlying state of the host immune system. Inhalation of A …

Aspergillus moulds exist ubiquitously as spores that are inhaled in large numbers daily.
Whilst most are removed by anatomical barriers, disease may occur in certain …