[HTML][HTML] The shifting lipidomic landscape of blood monocytes and neutrophils during pneumonia

AR Schuurman, O Chouchane, JM Butler… - JCI insight, 2024 - ncbi.nlm.nih.gov
The lipidome of immune cells during infection has remained unexplored, although evidence
of the importance of lipids in the context of immunity is mounting. In this study, we performed …

[HTML][HTML] Association of Altered Plasma Lipidome with Disease Severity in COVID-19 Patients

Z Zhang, N Karu, A Kindt, M Singh, L Lamont… - Biomolecules, 2024 - mdpi.com
The severity of COVID-19 is linked to an imbalanced immune response. The dysregulated
metabolism of small molecules and bioactive lipids has also been associated with disease …

Machine learning and semi-targeted lipidomics identify distinct serum lipid signatures in hospitalized COVID-19-positive and COVID-19-negative patients

H Castañé, S Iftimie, G Baiges-Gaya… - Metabolism, 2022 - Elsevier
Background Lipids are involved in the interaction between viral infection and the host
metabolic and immunological responses. Several studies comparing the lipidome of COVID …

Machine learning identified distinct serum lipidomic signatures in hospitalized COVID-19-positive and COVID-19-negative patients

H Castañé, S Iftimie, G Baiges-Gaya… - medRxiv, 2021 - medrxiv.org
Background Lipids are involved in the interaction between viral infection and the host
metabolic and immunological response. Several studies comparing the lipidome of COVID …

[HTML][HTML] Lipidomics signature in post-COVID patient sera and its influence on the prolonged inflammatory response

PF Garrido, LS Castillo-Peinado… - Journal of Infection and …, 2024 - Elsevier
Background The ongoing issues with post-COVID conditions (PCC), where symptoms
persist long after the initial infection, highlight the need for research into blood lipid changes …

[HTML][HTML] Lipid profiles and differential lipids in serum related to severity of community-acquired pneumonia: A pilot study

L Chen, Y Zheng, L Zhao, Y Zhang, L Yin, Y He, X Ma… - PloS one, 2021 - journals.plos.org
This study aimed to characterize the lipidomic responses to community-acquired pneumonia
(CAP) and provide new insight into the underlying mechanisms of pathogenesis and …

[HTML][HTML] Lipid alternations in the plasma of COVID-19 patients with various clinical presentations

X Liang, X Qi, J Yang, X Wang, H Qin, F Hu… - Frontiers in …, 2023 - frontiersin.org
Background COVID-19 is a highly infectious respiratory disease that can manifest in various
clinical presentations. Although many studies have reported the lipidomic signature of …

[HTML][HTML] E. coli strain-dependent lipid alterations in cocultures with endothelial cells and neutrophils modeling sepsis

K Amunugama, DP Pike, DA Ford - Frontiers in physiology, 2022 - frontiersin.org
Dysregulated lipid metabolism is common in infection and inflammation and is a part of the
complex milieu underlying the pathophysiological sequelae of disease. Sepsis is a major …

[HTML][HTML] A Lipid Map for Community-acquired Pneumonia with Sepsis: Observation Is the First Step in Scientific Progress

EJ Schenck, M Plataki, CE Wheelock - American Journal of …, 2024 - atsjournals.org
Community acquired pneumonia (CAP) with sepsis leads to over 350 thousand intensive
care unit (ICU) admissions in the USA annually, with an in-hospital mortality of 17% and a …

Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections

VC Tam - Seminars in immunology, 2013 - Elsevier
Bioactive lipid mediators play crucial roles in promoting the induction and resolution of
inflammation. Eicosanoids and other related unsaturated fatty acids have long been known …