Receptor tyrosine kinases (RTKs) are cell surface receptors that bind growth factor ligands
and initiate cellular signaling. Of the 20 classes of RTKs, 7 classes, IV, VIII, and X, are linked …

In this review, key aspects of epidermal growth factor receptor (EGFR) biology and the fruitful
translation of these fundamental findings into recent treatment advances in head and neck …

Importance of the field: EGFR is an established therapeutic target in head and neck
squamous cell carcinoma (HNSCC). The EGFR-targeting monoclonal antibody cetuximab …

The epidermal growth factor receptor (EGFR) has been shown to be a promising therapeutic
target in head and neck cancer. Cetuximab, a monoclonal antibody against EGFR, has been …

Despite extensive research in squamous cell carcinoma of the head and neck (SCCHN), the
epidermal growth factor receptor (EGFR) remains the only nonchemotherapeutic molecular …

Epidermal growth factor receptor (EGFR) is overexpressed in most head and neck cancers
and correlates with poor prognosis. In the past few years, numerous clinical trials for head …

As early detection strategies have not been successful, most patients with head and neck
cancer (HNC) present with advanced (stages III and IV) disease. Oral cavity tumors are …

New agents and treatment strategies that can be safely and effectively integrated into current
treatment paradigms for head and neck squamous cell carcinoma (HNSCC) are urgently …

The epidermal growth factor (EGF) and its receptor were discovered nearly 40 years ago.
Over the past decade interruption of this pathway has been exploited in the treatment of …

Squamous cell carcinoma of head and neck (SCCHN) is the most common neoplasm of the
upper aerodigestive tract. In this paper, we attempt to summarize the role and applications of …