Hepatocellular carcinoma (HCC) progression is closely related to pathological fibrosis,
which involves heterotypic intercellular interactions (HIIs) between liver cancer cells and …

Tumor angiogenesis plays a central role in the development and metastasis of
hepatocellular carcinoma. Cancer cells secrete angiogenic factors to recruit vascular …

The invasive and metastatic potentials of hepatocellular carcinoma (HCC) are positively
correlated with the expression level of α 3 β 1 integrin, a high-affinity adhesion receptor for …

Tumor microenvironment (TME) is the cellular environment in which tumor exists, and it
contributes to tumor formation and progression. The TME is composed of tumor cells …

Integrins are a family of transmembrane receptors that connect the extracellular matrix and
actin skeleton, which mediate cell adhesion, migration, signal transduction, and gene …

Nonalcoholic fatty liver disease (NAFLD) has become a major risk factor for hepatocellular
carcinoma (HCC) worldwide. However, the underlying mechanism remains insufficiently …

Blood vessel remodeling is crucial in tumor growth. Growth factors released by tumor cells
and endothelium-extracellular matrix interactions are highlighted in tumor angiogenesis …

In addition to being an important mediator of migration and invasion of tumor cells, β3
integrin can also enhance TGF-β1 signaling. However, it is not known whether β3 might …

Abstract Background Interleukin-8 (IL-8) plays a vital role in the invasion and metastasis of
hepatocellular carcinoma (HCC), and is closely associated with poor prognosis of HCC …

Purpose: This study evaluates the proapoptotic function of integrin β3 in human
hepatocellular carcinoma (HCC). Experimental Design: The expression of integrin β3 in 67 …