This paper presents the development of a fiber-optic-based fluorescence detection system
for multi-scale monitoring of drug distribution in living animals. The integrated system utilized …

Real-time fluorescence measurement in deep tumors in live animals (or humans) by
conventional methods has significant challenges. We have developed a two-photon optical …

Label-free optical microscopy has matured as a noninvasive tool for biological imaging; yet,
it is criticized for its lack of specificity, slow acquisition and processing times, and weak and …

High-content screening (HCS) and high-throughput screening (HTS) are common processes
used in biological research and drug discovery. They allow rapid examination of thousands …

The detection and quantification of the concentration of exogenous chromophores in-vivo by
their fluorescence is complicated by many physical and geometrical parameters …

We present an optical system for small animal imaging that can combine various in vivo
imaging modalities, including fluorescence (intensity and lifetime), spectral, and trans …

Optical imaging is an emerging field with a wide range of biomedical research and clinical
applications, both current and future. It comprises several classes of techniques that are …

Purpose Several established optical imaging approaches have been applied, usually in
isolation, to preclinical studies; however, truly useful in vivo imaging may require a …

This thesis reports advanced optical imaging technology in a stand-alone system that
enables functional mesoscopic imaging (whole-body or endoscopic imaging with …

The visualization of drugs in living systems has become key techniques in modern
therapeutics. Recent advancements in optical imaging technologies and molecular design …