From the gut to the peripheral tissues: the multiple effects of butyrate

P Guilloteau, L Martin, V Eeckhaut… - Nutrition research …, 2010 - cambridge.org
Butyrate is a natural substance present in biological liquids and tissues. The present paper
aims to give an update on the biological role of butyrate in mammals, when it is naturally …

[HTML][HTML] Implications of butyrate and its derivatives for gut health and animal production

A Bedford, J Gong - Animal Nutrition, 2018 - Elsevier
Butyrate is produced by microbial fermentation in the large intestine of humans and animals.
It serves as not only a primary nutrient that provides energy to colonocytes, but also a …

[HTML][HTML] Butyrate's role in human health and the current progress towards its clinical application to treat gastrointestinal disease

K Hodgkinson, F El Abbar, P Dobranowski… - Clinical Nutrition, 2023 - Elsevier
Butyrate is a key energy source for colonocytes and is produced by the gut microbiota
through fermentation of dietary fiber. Butyrate is a histone deacetylase inhibitor and also …

[HTML][HTML] Butyrate: a double-edged sword for health?

H Liu, J Wang, T He, S Becker, G Zhang, D Li, X Ma - Advances in nutrition, 2018 - Elsevier
Butyrate, a four-carbon short-chain fatty acid, is produced through microbial fermentation of
dietary fibers in the lower intestinal tract. Endogenous butyrate production, delivery, and …

The role of butyrate on colonic function

HM Hamer, D Jonkers, K Venema… - Alimentary …, 2008 - Wiley Online Library
Background Butyrate, a short‐chain fatty acid, is a main end‐product of intestinal microbial
fermentation of mainly dietary fibre. Butyrate is an important energy source for intestinal …

[HTML][HTML] Potential beneficial effects of butyrate in intestinal and extraintestinal diseases

RB Canani, M Di Costanzo, L Leone… - World journal of …, 2011 - ncbi.nlm.nih.gov
The multiple beneficial effects on human health of the short-chain fatty acid butyrate,
synthesized from non-absorbed carbohydrate by colonic microbiota, are well documented …

Butyrate: implications for intestinal function

AJ Leonel, JI Alvarez-Leite - Current Opinion in Clinical Nutrition & …, 2012 - journals.lww.com
From studies published over 30 years, there is no doubt of the important role that butyrate
plays in maintaining intestinal homeostasis. However, despite these effects, clinical studies …

Impact of diet-modulated butyrate production on intestinal barrier function and inflammation

KE Bach Knudsen, HN Lærke, MS Hedemann… - Nutrients, 2018 - mdpi.com
A major challenge in affluent societies is the increase in disorders related to gut and
metabolic health. Chronic over nutrition by unhealthy foods high in energy, fat, and sugar …

Gut microbial metabolite butyrate and its therapeutic role in inflammatory bowel disease: a literature review

N Recharla, R Geesala, XZ Shi - Nutrients, 2023 - mdpi.com
Background and objective: Inflammatory bowel disease (IBD), including Crohn's disease
and ulcerative colitis, is a chronic inflammatory disorder characterized by aberrant immune …

The butyrate story: old wine in new bottles?

W Scheppach, F Weiler - Current Opinion in Clinical Nutrition & …, 2004 - journals.lww.com
In the era of molecular biology our understanding of subcellular processes that ultimately
lead to inflammatory bowel disease or colorectal cancer has widened considerably. The …