The present systematic review was aimed at critically summarizing the evidence about
treatment-emergent manic/hypomanic and depressive switches during the course of bipolar …

The present study investigated possible clinical differences between bipolar patients with
and without manic or hypomanic switch during antidepressant (AD) treatment. The authors …

Objective: Antidepressant safety and efficacy remain controversial for the treatment of
bipolar depression. The present study utilized data from the National Institute of Mental …

With the increasingly widespread use of antipsychotics in bipolar disorder (BD), switching
among these agents and between antipsychotics and mood stabilizers has become more …

Antidepressant-induced switching is a major risk during the treatment of bipolar depression.
Despite several clinical studies, questions remain regarding both the definition of these …

Objective: Treatment of bipolar depression with antidepressants is strongly debated on the
basis of the methodologically poor and insufficient data supporting their use and the widely …

Introduction: Bipolar patients with breakthrough major depressive episodes despite ongoing
adequately‐dosed mood stabilizer medication were randomized in a double‐blind manner …

BACKGROUND: The risk of switching from mania to depression in bipolar disorder has been
poorly studied. Large observational studies may be useful in identifying variables that …

Background: Case observations imply that depressed patients with mixed features are of
high risk for maniform switch during acute treatment. Methods: The medical records of 158 …

Background Treatment‐emergent mania (TEM) represents a common phenomenon
inconsistently reported across primary studies, warranting further assessment. Methods A …