Chemotherapy, nerve injuries, or diseases like multiple sclerosis can cause
pathophysiological processes of persistent and neuropathic pain. Thereby, the activation …

Lipid derived mediators contribute to inflammation and the sensing of pain. The
contributions of omega-6 derived prostanoids in enhancing inflammation and pain sensation …

Inflammatory pain serves as a protective defense mechanism which becomes pathological
when it turns into chronic inflammatory pain. This transition is mediated by a variety of …

Beneficial physiological effects of long-chain n-3 polyunsaturated fatty acids are widely
accepted but the mechanism (s) by which these fatty acids act remains unclear. Herein, we …

Eicosanoids play a crucial role in inflammatory pain. However, there is very little knowledge
about the contribution of oxidized linoleic acid metabolites in inflammatory pain and …

The role of lipids in pain signaling is well established and built on decades of knowledge
about the pain and inflammation produced by prostaglandin and leukotriene metabolites of …

Lipids have long been studied as constituents of the cellular architecture and energy stores
in the body. Evidence is now rapidly growing that particular lipid species are also important …

Pain is a complex sensation that may be protective or cause undue suffering and loss of
function, depending on the circumstances. Peripheral nociceptor neurons (PNs) innervate …

Environmental or internal noxious stimuli excite the primary sensory nerves in our body. The
sensory nerves relay these signals by electrical discharges to the brain, leading to pain …

Chronic pain (CP) is a severe clinical entity with devastating physical and emotional
consequences for patients, which can occur in a myriad of diseases. Often, conventional …