Simple Summary Since the targeting of a single pro-angiogenic factor fails to improve
oncological disease outcome, significant efforts have been made to identify new pro …

This article reviews the evidence for macrophages playing an important role in the
regulation of tumor angiogenesis. Findings in mouse models show that macrophages …

Tumor vascularization is a highly complex process that involves the interaction between
tumors and their surrounding stroma, as well as many distinct angiogenesis-regulating …

Angiogenesis, the formation of new capillary blood vessels from preexisting vasculature, is
one of the hallmarks of cancer that is pivotal for tumor growth and metastasis. Tumor vessels …

Macrophages are prominent in the stromal compartment of virtually all types of malignancy.
These highly versatile cells respond to the presence of stimuli in different parts of tumors …

One of the functions of macrophages is to provide a defense mechanism against tumor cells.
In contrast, tumor-associated macrophages (TAMs), which represent the major inflammatory …

Tumor-associated macrophages (TAMs) are a prominent inflammatory cell population in
many tumor types residing in both perivascular and avascular, hypoxic regions of these …

Tumor associated macrophages (TAMs) are the most frequent immune cells within tumor
microenvironment (TME). There is growing evidence that TAMs are involved in tumor …

Tumor-associated macrophages (TAM) are key regulators of the link between inflammation
and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and …

The role of a tumor immune infiltrate in cancer progression and metastasis has been
debated frequently. Although often considered to be associated with improved prognosis …