Pancreatic Neuroendocrine Tumors: Signaling Pathways and Epigenetic Regulation

Z Saleh, MC Moccia, Z Ladd, U Joneja, Y Li… - International Journal of …, 2024 - mdpi.com
Pancreatic neuroendocrine tumors (PNETs) are characterized by dysregulated signaling
pathways that are crucial for tumor formation and progression. The efficacy of traditional …

Pancreatic neuroendocrine tumors: molecular mechanisms and therapeutic targets

CK Maharjan, PH Ear, CG Tran, JR Howe… - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers
whose causation is only partly understood. An increasing number of studies have uncovered …

Molecular biology of pancreatic neuroendocrine tumors: From mechanism to translation

X Shen, X Wang, X Lu, Y Zhao, W Guan - Frontiers in Oncology, 2022 - frontiersin.org
Pancreatic neuroendocrine tumors (pNETs) are a group of heterogeneous tumors originated
from progenitor cells. As these tumors are predominantly non-functional, most of them …

[HTML][HTML] Insights into the biology and treatment strategies of pancreatic neuroendocrine tumors

JL Buicko, BM Finnerty, T Zhang, BJ Kim… - Annals of pancreatic …, 2019 - ncbi.nlm.nih.gov
Pancreatic neuroendocrine tumors (PNETs) are the second most common primary
pancreatic neoplasms after pancreatic ductal adenocarcinoma. PNETs present with widely …

Molecular profile of pancreatic neuroendocrine neoplasms (PanNENs): Opportunities for personalized therapies

J Arakelyan, D Zohrabyan, PA Philip - Cancer, 2021 - Wiley Online Library
Pancreatic neuroendocrine neoplasms (panNENs) are the second most common epithelial
tumors of the pancreas. Despite improvements in prognostic grading and staging systems, it …

Molecular signatures and their clinical utility in pancreatic neuroendocrine tumors

PD Chatani, SK Agarwal, SM Sadowski - Frontiers in Endocrinology, 2021 - frontiersin.org
Pancreatic neuroendocrine tumors (PNETs) are classified based on their histologic
differentiation and proliferative indices, which have been used extensively to determine …

The evolving (epi) genetic landscape of pancreatic neuroendocrine tumours

CP Pipinikas, AM Berner, T Sposito… - Endocrine-related …, 2019 - erc.bioscientifica.com
Neuroendocrine neoplasms (NENs) are a relatively rare group of heterogeneous tumours
originating from neuroendocrine cells found throughout the body. Pancreatic NENs …

Molecular profiling of pancreatic neuroendocrine tumors (pNETS) and the clinical potential

M Camilli, K Papadimitriou, A Nogueira… - Expert review of …, 2018 - Taylor & Francis
Introduction: Pancreatic neuroendocrine tumors (pNETs) represent a small part of pancreatic
neoplasms, and the knowledge about their indolent clinical course remains a subject of …

Dictating genomic destiny: Epigenetic regulation of pancreatic neuroendocrine tumours

JS Gundara, K Jamal, T Kurzawinski - Molecular and Cellular …, 2018 - Elsevier
Pancreatic neuroendocrine tumours are a diverse group of neoplasms with an increasingly
well-defined genomic basis. Despite this, much of what drives this disease is still unknown …

Genetics of pancreatic neuroendocrine tumors: implications for the clinic

A Pea, RH Hruban, LD Wood - Expert review of gastroenterology & …, 2015 - Taylor & Francis
Pancreatic neuroendocrine tumors (PanNETs) are a common and deadly neoplasm of the
pancreas. Although the importance of genetic alterations in PanNETs has been known for …