Background Pubertal growth patterns correlate with future health outcomes. However, the
genetic mechanisms mediating growth trajectories remain largely unknown. Here, we …

Early childhood growth patterns are associated with adult health, yet the genetic factors and
the developmental stages involved are not fully understood. Here, we combine genome …

Puberty, the transition from childhood to adult body size and sexual maturity, is a complex
multi-staged process involving growth acceleration, weight gain and the appearance of …

The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both
the central onset of puberty and local growth factors. Although little is known about the …

Puberty is a highly variable developmental stage marked by the development of secondary
sex characteristics and the attainment of reproductive maturity. Variation during childhood …

Early or late pubertal onset can lead to disease in adulthood, including cancer, obesity, type
2 diabetes, metabolic disorders, bone fractures and psychopathologies. Thus, knowing the …

Genetic effects on changes in human traits over time are understudied and may have
important pathophysiological impact. We propose a framework that enables data quality …

Understanding of the genetic regulation of puberty timing has come largely from studies of
rare disorders and population-based studies in women. Here, we report the largest genomic …

Despite the high heritability of human growth traits, until recently little was known about the
underlying genes and genetic variants which explain normal variation of growth. In the past …

Growth is a complex process composed of distinct phases over the course of childhood.
Although the pubertal growth spurt has received the most attention from auxologists and …