Chemicals used for the induction of Alzheimer's disease-like cognitive dysfunctions in rodents

O Mahdi, MTH Baharuldin, NHM Nor… - Biomedical Research …, 2019 - biomedpress.org
Alzheimer's disease (AD) is the most frequent and multifactorial form of dementia,
characterised by multiple cognitive impairments and personality changes. Different methods …

A systematic review for the development of Alzheimer's disease in in vitro models: a focus on different inducing agents

M Prajapat, G Kaur, G Choudhary, P Pahwa… - Frontiers in Aging …, 2023 - frontiersin.org
Alzheimer's disease (AD) is the most common progressive neurodegenerative disease and
is associated with dementia. Presently, various chemical and environmental agents are …

Role of neurotoxicants in the pathogenesis of Alzheimer's disease: a mechanistic insight

FY Nisa, MA Rahman, MA Hossen, MF Khan… - Annals of …, 2021 - Taylor & Francis
Alzheimer's disease (AD) is the most conspicuous chronic neurodegenerative syndrome,
which has become a significant challenge for the global healthcare system. Multiple studies …

Animal models of Alzheimer's disease: An origin of innovative treatments and insight to the disease's etiology

RS Chavan, KV Supalkar, SS Sadar, NS Vyawahare - Brain Research, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder. The main
pathogenic features are the development and deposition of senile plaques and …

Alzheimer's disease animal models: elucidation of biomarkers and therapeutic approaches for cognitive impairment

T Nakai, K Yamada, H Mizoguchi - International journal of molecular …, 2021 - mdpi.com
Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder. It
is widely accepted that AD is mainly caused by the accumulation of extracellular amyloid β …

Therapeutic effects of natural drugs on Alzheimer's disease

Y Ma, M Yang, X Li, J Yue, J Chen, M Yang… - Frontiers in …, 2019 - frontiersin.org
Alzheimer disease (AD) is characterized as a chronic neurodegenerative disease
associated with aging. The clinical manifestations of AD include latent episodes of memory …

Bridging the gap between Alzheimer's disease and Alzheimer's-like diseases in animals

A Gołaszewska, W Bik, T Motyl… - International journal of …, 2019 - mdpi.com
The average life span steadily grows in humans and in animals kept as pets or left in
sanctuaries making the issue of elderly-associated cognitive impairment a hot-spot for …

Pathogenesis, Animal Models, and Drug Discovery of Alzheimer's Disease

ZD Xia, RX Ma, JF Wen, YF Zhai… - Journal of …, 2023 - content.iospress.com
Alzheimer's disease (AD), the most common cause of dementia, is a chronic
neurodegenerative disease induced by multiple factors. The high incidence and the aging of …

Neurotransmitters in prevention and treatment of Alzheimer's disease

Z Yang, Y Zou, L Wang - International Journal of Molecular Sciences, 2023 - mdpi.com
Alzheimer's disease (AD) is the most frequent cause of cognitive impairment in middle-aged
and older populations. There is a lack of drugs that demonstrate significant efficacy in AD, so …

Insight into the emerging and common experimental in-vivo models of Alzheimer's disease

R Dhapola, S Kumari, P Sharma… - Laboratory Animal …, 2023 - Springer
Alzheimer's disease (AD) is a multifactorial, rapidly progressing neurodegenerative disorder.
As the exact cause of the disease is still unclear, the drug development is very challenging …