[HTML][HTML] Mechanisms of action of fluvoxamine for COVID-19: a historical review

Y Hashimoto, T Suzuki, K Hashimoto - Molecular psychiatry, 2022 - nature.com
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) accelerates the discovery of …

[HTML][HTML] Potential Role of the Antidepressants Fluoxetine and Fluvoxamine in the Treatment of COVID-19

M Mahdi, L Hermán, JM Réthelyi, BL Bálint - International Journal of …, 2022 - mdpi.com
Mapping non-canonical cellular pathways affected by approved medications can accelerate
drug repurposing efforts, which are crucial in situations with a global impact such as the …

Drug repurposing of selective serotonin reuptake inhibitors: Could these drugs help fight COVID-19 and save lives?

Y Pashaei - Journal of Clinical Neuroscience, 2021 - Elsevier
The current 2019 novel coronavirus disease (COVID-19), an emerging infectious disease, is
undoubtedly the most challenging pandemic in the 21st century. A total of 92,977,768 …

[HTML][HTML] Fluvoxamine for the early treatment of SARS-CoV-2 infection: a review of current evidence

SN Facente, AM Reiersen, EJ Lenze, DR Boulware… - Drugs, 2021 - Springer
SARS-CoV-2 infection causes COVID-19, which frequently leads to clinical deterioration
and/or long-lasting morbidity. Academic and governmental experts throughout the USA met …

[HTML][HTML] Fluvoxamine: a review of its mechanism of action and its role in COVID-19

VP Sukhatme, AM Reiersen, SJ Vayttaden… - Frontiers in …, 2021 - frontiersin.org
Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake
inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized …

[HTML][HTML] Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro

SM Fred, S Kuivanen, H Ugurlu… - Frontiers in …, 2022 - frontiersin.org
Repurposing of currently available drugs is a valuable strategy to tackle the consequences
of COVID-19. Recently, several studies have investigated the effect of psychoactive drugs on …

[HTML][HTML] Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19: current evidence and potential mechanisms

N Hoertel, M Sánchez-Rico, C Cougoule… - Molecular …, 2021 - nature.com
We read with great interest the correspondence letters of Salles et al.[1] and Stip et al.[2],
following our multicenter observational retrospective study that showed a substantial …

Do the selective serotonin reuptake inhibitor antidepressants fluoxetine and fluvoxamine reduce mortality among patients with COVID-19?

N Hoertel - JAMA network open, 2021 - jamanetwork.com
In a large, multicenter, retrospective cohort study of 83 584 patients with laboratory-
confirmed COVID-19 who had an emergency department or urgent care visit or were …

[HTML][HTML] Efficacy and safety of selective serotonin reuptake inhibitors in COVID-19 management: a systematic review and meta-analysis

J Deng, D Rayner, HB Ramaraju, U Abbas… - Clinical Microbiology …, 2023 - Elsevier
Background The efficacy of selective serotonin reuptake inhibitors (SSRIs) in the treatment
of acute COVID-19 is still under investigation, with conflicting results reported from …

[HTML][HTML] The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 in human lung tissue

M Zimniak, L Kirschner, H Hilpert, N Geiger, O Danov… - Scientific reports, 2021 - nature.com
To circumvent time-consuming clinical trials, testing whether existing drugs are effective
inhibitors of SARS-CoV-2, has led to the discovery of Remdesivir. We decided to follow this …