A computational analysis on the impact of multilevel laryngotracheal stenosis on airflow and drug particle dynamics in the upper airway

RE Gosman, RM Sicard, SM Cohen… - Experimental and …, 2023 - Springer
Laryngotracheal stenosis (LTS) is a type of airway narrowing that is frequently caused by
intubation-related trauma. LTS can occur at one or multiple locations in the larynx and/or …

Comparison of Inhaled Drug Delivery in Patients With One‐and Two‐level Laryngotracheal Stenosis

RE Gosman, RM Sicard, SM Cohen… - The …, 2023 - Wiley Online Library
Objectives/Hypothesis Laryngotracheal stenosis (LTS) is a functionally devastating condition
with high respiratory morbidity and mortality. This preliminary study investigates airflow …

Orally inhaled drug particle transport in computerized models of laryngotracheal stenosis

DO Frank-Ito, SM Cohen - Otolaryngology–Head and Neck …, 2021 - journals.sagepub.com
Objective Adjuvant management for laryngotracheal stenosis (LTS) may involve inhaled
corticosteroids, but metered dose inhalers are designed for pulmonary drug delivery …

Tracheal stenosis: a CFD approach for evaluation of drug delivery

S Taherian, H Rahai, BZ Gomez… - ASME …, 2015 - asmedigitalcollection.asme.org
The existence of obstructions such as tracheal stenosis has major impacts on respiratory
functions. Therapeutic effectiveness of inhaled medications is influenced by tracheal …

The application of computational fluid dynamics in the evaluation of laryngotracheal pathology

EC Mason, S McGhee, K Zhao… - Annals of Otology …, 2019 - journals.sagepub.com
Objectives: Laryngotracheal stenosis and obstruction can be challenging to manage.
Traditional assessment tools are limited in clinical correlation. Three-dimensional …

How nanoparticle aerosols transport through multi-stenosis sections of upper airways: A CFD-DPM modelling

MR Islam, P Larpruenrudee, MM Rahman, S Ullah… - Atmosphere, 2022 - mdpi.com
Airway stenosis is a global respiratory health problem that is caused by airway injury,
endotracheal intubation, malignant tumor, lung aging, or autoimmune diseases. A precise …

Model for Pharmaceutical aerosol transport through stenosis airway

P Larpruenrudee, MS Islam, G Paul… - Handbook of Lung …, 2021 - api.taylorfrancis.com
Air pollution is one of the critical factors that has threatened human health for a long time. In
the early 20th century, people worldwide were aware of the health effects that were caused …

Particulate deposition in a patient with tracheal stenosis

S Taherian, HR Rahai… - … and Science in …, 2018 - asmedigitalcollection.asme.org
The presence of obstructions such as tracheal stenosis has important effects on respiratory
functions. Tracheal stenosis impacts the therapeutic efficacy of inhaled medications as a …

[图书][B] Computational flow modeling of human upper airway breathing

G Mylavarapu - 2013 - search.proquest.com
Computational modeling of biological systems have gained a lot of interest in biomedical
research, in the recent past. This thesis focuses on the application of computational …

Glottal motion and its impact on airflow and aerosol deposition in upper airways during human breathing

A Scheinherr - 2015 - theses.hal.science
During inhaled therapies several factors limits the amount of drug delivered to the lungs. Eg
the upper airways morphology and in particular the glottis, defined by the vocal-fold …