The NorR Protein of Escherichia coli Activates Expression of the Flavorubredoxin Gene norV in Response to Reactive Nitrogen Species

MI Hutchings, N Mandhana, S Spiro - Journal of Bacteriology, 2002 - Am Soc Microbiol
The Escherichia coli norVW genes encode a flavorubredoxin and NADH:(flavo) rubredoxin
reductase, respectively, which are involved in nitric oxide detoxification under anaerobic …

Regulation of the flavorubredoxin nitric oxide reductase gene in Escherichia coli: nitrate repression, nitrite induction, and possible post-transcription control

PN da Costa, M Teixeira… - FEMS microbiology …, 2003 - academic.oup.com
Escherichia coli flavorubredoxin is a new type of cytoplasmic nitric oxide (NO) reductase,
which shows NO reductase activity within the range of the canonical membrane-bound …

Mechanism of transcriptional regulation by the Escherichia coli nitric oxide sensor NorR

NP Tucker, B D'autréaux, S Spiro… - Biochemical Society …, 2006 - portlandpress.com
Nitric oxide (NO) is a highly reactive water-soluble gas encountered by bacteria
endogenously as an intermediate of denitrification and exogenously as one of the radical …

Transcriptional regulation by the dedicated nitric oxide sensor, NorR: a route towards NO detoxification

M Bush, T Ghosh, N Tucker, X Zhang… - Biochemical Society …, 2011 - portlandpress.com
A flavorubredoxin and its associated oxidoreductase (encoded by norV and norW
respectively) detoxify NO (nitric oxide) to form N2O (nitrous oxide) under anaerobic …

Flavorubredoxin, an inducible catalyst for nitric oxide reduction and detoxification in Escherichia coli

AM Gardner, RA Helmick, PR Gardner - Journal of Biological Chemistry, 2002 - ASBMB
Nitric oxide (NO) is a poison, and organisms employ diverse systems to protect against its
harmful effects. InEscherichia coli, ygaA encodes a transcription regulator (b2709) …

A non-haem iron centre in the transcription factor NorR senses nitric oxide

B D'Autréaux, NP Tucker, R Dixon, S Spiro - Nature, 2005 - nature.com
Nitric oxide (NO), synthesized in eukaryotes by the NO synthases, has multiple roles in
signalling pathways and in protection against pathogens,. Pathogenic microorganisms have …

Regulation of the Nitric Oxide Reduction Operon (norRVW) in Escherichia coli: ROLE OF NorR AND ς54 IN THE NITRIC OXIDE STRESS RESPONSE

AM Gardner, CR Gessner, PR Gardner - Journal of Biological Chemistry, 2003 - ASBMB
Nitric oxide (NO) induces NO-detoxifying enzymes in Escherichia coli suggesting sensitive
mechanisms for coordinate control of NO defense genes in response to NO stress. Exposure …

Detoxification of nitric oxide by the flavorubredoxin of Salmonella enterica serovar Typhimurium

PC Mills, DJ Richardson, JCD Hinton, S Spiro - 2005 - portlandpress.com
Salmonella possesses multiple enzymes that utilize NO as a substrate, and could therefore
contribute to the organism's ability to resist nitrosative killing by macrophages …

Nitrosative stress in Escherichia coli: reduction of nitric oxide

CE Vine, JA Cole - 2011 - portlandpress.com
The ability of enteric bacteria to protect themselves against reactive nitrogen species
generated by their own metabolism, or as part of the innate immune response, is critical to …

DNA Binding Activity of the Escherichia coli Nitric Oxide Sensor NorR Suggests a Conserved Target Sequence in Diverse Proteobacteria

NP Tucker, B D'autreaux, DJ Studholme… - Journal of …, 2004 - Am Soc Microbiol
The Escherichia coli nitric oxide sensor NorR was shown to bind to the promoter region of
the norVW transcription unit, forming at least two distinct complexes detectable by gel …