[HTML][HTML] MiRNAs and piRNAs from bone marrow mesenchymal stem cell extracellular vesicles induce cell survival and inhibit cell differentiation of cord blood …

L De Luca, S Trino, I Laurenzana, V Simeon, G Calice… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Hematopoietic stem cells (HSC), including umbilical cord blood CD34+ stem cells (UCB-
CD34+), are used for the treatment of several diseases. Although different studies suggest …

Extracellular vesicle microRNA and protein cargo profiling in three clinical-grade stem cell products reveals key functional pathways

R Vaka, S Parent, Y Risha, S Khan, D Courtman… - … Therapy-Nucleic Acids, 2023 - cell.com
The cell origin-specific payloads within extracellular vesicles (EVs) mediate therapeutic
bioactivity for a wide variety of stem cell types. In this study, we profiled the microRNA …

Osteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cells

J Morhayim, J Van De Peppel, E Braakman… - Scientific reports, 2016 - nature.com
Osteolineage cells represent one of the critical bone marrow niche components that support
maintenance of hematopoietic stem and progenitor cells (HSPCs). Recent studies …

Mesenchymal stem cell-derived extracellular vesicles affect disease outcomes via transfer of microRNAs

G Qiu, G Zheng, M Ge, J Wang, R Huang… - Stem Cell Research & …, 2018 - Springer
Mesenchymal stem cells (MSCs) are adult stromal cells with the capacity to differentiate into
multiple types of cells. MSCs represent an attractive option in regenerative medicine due to …

[HTML][HTML] The effect of mesenchymal stem cell-derived extracellular vesicles on hematopoietic stem cells fate

H Timari, K Shamsasenjan… - Advanced …, 2017 - ncbi.nlm.nih.gov
Hematopoietic stem cells (HSCs) are multipotent stem cells, with self-renewal ability as well
as ability to generate all blood cells. Mesenchymal stem cells (MSCs) are multipotent stem …

Human umbilical cord mesenchymal stem cell-derived extracellular vesicles promote lung adenocarcinoma growth by transferring miR-410

L Dong, Y Pu, L Zhang, Q Qi, L Xu, W Li, C Wei… - Cell death & …, 2018 - nature.com
Although accumulating evidence has linked mesenchymal stem cells (MSCs) with tumor
growth, the underlying mechanisms are poorly understood. Here, we demonstrated for the …

Small non-coding RNA landscape of extracellular vesicles from human stem cells

S Kaur, AG Abu-Shahba, RO Paananen, H Hongisto… - Scientific reports, 2018 - nature.com
Extracellular vesicles (EVs) are reported to be involved in stem cell maintenance, self-
renewal, and differentiation. Due to their bioactive cargoes influencing cell fate and function …

Mesenchymal stromal cell-derived extracellular vesicles: novel approach in hematopoietic stem cell transplantation

DP Sarvar, H Effatpanah, P Akbarzadehlaleh… - Stem Cell Research & …, 2022 - Springer
Bone marrow mesenchymal stromal cells (MSCs) play a crucial role in the regulation of
hematopoiesis. These cells affect the process through direct cell–cell contact, as well as …

[HTML][HTML] Interferon-γ and hypoxia priming have limited effect on the miRNA landscape of human mesenchymal stromal cells-derived extracellular vesicles

J Peltzer, K Lund, ME Goriot, M Grosbot… - Frontiers in Cell and …, 2020 - frontiersin.org
Mesenchymal stromal cell (MSC)-based cell therapy has received great interest in
regenerative medicine. Priming the cells during the culture phase can improve their efficacy …

Preclinical experimental applications of miRNA loaded BMSC extracellular vesicles

Z Cetin, EI Saygili, G Görgisen, E Sokullu - Stem cell reviews and reports, 2021 - Springer
Bone marrow mesenchymal stem cells have been investigated for many years, especially for
tissue regeneration, and have inherent limitations. One of the rapidly developing fields in the …