The role of GABAergic signalling in neurodevelopmental disorders

X Tang, R Jaenisch, M Sur - Nature Reviews Neuroscience, 2021 - nature.com
GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of
exciting new discoveries provides compelling evidence that disruptions in a number of key …

[HTML][HTML] Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic …

G Deidda, IF Bozarth, L Cancedda - Frontiers in cellular neuroscience, 2014 - frontiersin.org
During mammalian ontogenesis, the neurotransmitter GABA is a fundamental regulator of
neuronal networks. In neuronal development, GABAergic signaling regulates neural …

The contribution of GABAergic dysfunction to neurodevelopmental disorders

K Ramamoorthi, Y Lin - Trends in molecular medicine, 2011 - cell.com
GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. The
GABAergic system is indispensable for maintaining the balance between excitation and …

GABA type a receptor trafficking and the architecture of synaptic inhibition

JM Lorenz‐Guertin, TC Jacob - Developmental neurobiology, 2018 - Wiley Online Library
Ubiquitous expression of GABA type A receptors (GABAAR) in the central nervous system
establishes their central role in coordinating most aspects of neural function and …

[HTML][HTML] Dysregulation of GABAergic signaling in neurodevelomental disorders: targeting cation-chloride co-transporters to re-establish a proper E/I balance

E Cherubini, G Di Cristo, M Avoli - Frontiers in cellular neuroscience, 2022 - frontiersin.org
The construction of the brain relies on a series of well-defined genetically and experience-or
activity-dependent mechanisms which allow to adapt to the external environment. Disruption …

GABA receptors in brain development, function, and injury

C Wu, D Sun - Metabolic brain disease, 2015 - Springer
This review presents a brief overview of the γ-aminobutyric acid (GABA) system in the
developing and mature central nervous system (CNS) and its potential connections to …

Refining the roles of GABAergic signaling during neural circuit formation

CJ Akerman, HT Cline - Trends in neurosciences, 2007 - cell.com
Our understanding of the role of GABA signaling in circuit development is rapidly expanding.
Here, we review three recent refinements in our understanding of the diverse roles that …

The GABA excitatory/inhibitory shift in brain maturation and neurological disorders

Y Ben-Ari, I Khalilov, KT Kahle… - The …, 2012 - journals.sagepub.com
Ionic currents and the network-driven patterns they generate differ in immature and adult
neurons: The developing brain is not a “small adult brain.” One of the most investigated …

[HTML][HTML] Alterations in GABAA-Receptor Trafficking and Synaptic Dysfunction in Brain Disorders

M Mele, RO Costa, CB Duarte - Frontiers in cellular neuroscience, 2019 - frontiersin.org
GABAA receptors (GABAAR) are the major players in fast inhibitory neurotransmission in the
central nervous system (CNS). Regulation of GABAAR trafficking and the control of their …

GABAergic circuit dysfunctions in neurodevelopmental disorders

B Chattopadhyaya, GD Cristo - Frontiers in psychiatry, 2012 - frontiersin.org
GABAergic interneurons control neuronal excitability, integration, and plasticity. Further, they
regulate the generation of temporal synchrony and oscillatory behavior among networks of …