The role of GABAergic signalling in neurodevelopmental disorders
GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of
exciting new discoveries provides compelling evidence that disruptions in a number of key …
exciting new discoveries provides compelling evidence that disruptions in a number of key …
[HTML][HTML] Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic …
G Deidda, IF Bozarth, L Cancedda - Frontiers in cellular neuroscience, 2014 - frontiersin.org
During mammalian ontogenesis, the neurotransmitter GABA is a fundamental regulator of
neuronal networks. In neuronal development, GABAergic signaling regulates neural …
neuronal networks. In neuronal development, GABAergic signaling regulates neural …
The contribution of GABAergic dysfunction to neurodevelopmental disorders
K Ramamoorthi, Y Lin - Trends in molecular medicine, 2011 - cell.com
GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. The
GABAergic system is indispensable for maintaining the balance between excitation and …
GABAergic system is indispensable for maintaining the balance between excitation and …
GABA type a receptor trafficking and the architecture of synaptic inhibition
JM Lorenz‐Guertin, TC Jacob - Developmental neurobiology, 2018 - Wiley Online Library
Ubiquitous expression of GABA type A receptors (GABAAR) in the central nervous system
establishes their central role in coordinating most aspects of neural function and …
establishes their central role in coordinating most aspects of neural function and …
[HTML][HTML] Dysregulation of GABAergic signaling in neurodevelomental disorders: targeting cation-chloride co-transporters to re-establish a proper E/I balance
The construction of the brain relies on a series of well-defined genetically and experience-or
activity-dependent mechanisms which allow to adapt to the external environment. Disruption …
activity-dependent mechanisms which allow to adapt to the external environment. Disruption …
GABA receptors in brain development, function, and injury
C Wu, D Sun - Metabolic brain disease, 2015 - Springer
This review presents a brief overview of the γ-aminobutyric acid (GABA) system in the
developing and mature central nervous system (CNS) and its potential connections to …
developing and mature central nervous system (CNS) and its potential connections to …
Refining the roles of GABAergic signaling during neural circuit formation
CJ Akerman, HT Cline - Trends in neurosciences, 2007 - cell.com
Our understanding of the role of GABA signaling in circuit development is rapidly expanding.
Here, we review three recent refinements in our understanding of the diverse roles that …
Here, we review three recent refinements in our understanding of the diverse roles that …
The GABA excitatory/inhibitory shift in brain maturation and neurological disorders
Y Ben-Ari, I Khalilov, KT Kahle… - The …, 2012 - journals.sagepub.com
Ionic currents and the network-driven patterns they generate differ in immature and adult
neurons: The developing brain is not a “small adult brain.” One of the most investigated …
neurons: The developing brain is not a “small adult brain.” One of the most investigated …
[HTML][HTML] Alterations in GABAA-Receptor Trafficking and Synaptic Dysfunction in Brain Disorders
GABAA receptors (GABAAR) are the major players in fast inhibitory neurotransmission in the
central nervous system (CNS). Regulation of GABAAR trafficking and the control of their …
central nervous system (CNS). Regulation of GABAAR trafficking and the control of their …
GABAergic circuit dysfunctions in neurodevelopmental disorders
B Chattopadhyaya, GD Cristo - Frontiers in psychiatry, 2012 - frontiersin.org
GABAergic interneurons control neuronal excitability, integration, and plasticity. Further, they
regulate the generation of temporal synchrony and oscillatory behavior among networks of …
regulate the generation of temporal synchrony and oscillatory behavior among networks of …