Two-component, self-assembling nanoparticles represent a versatile platform for multivalent
presentation of viral antigens. Computational design of protein nanoparticles with differing …

Multivalent presentation of viral glycoproteins can substantially increase the elicitation of
antigen-specific antibodies. To enable a new generation of anti-viral vaccines, we designed …

Structures of BG505 SOSIP. 664 trimer in complex with broadly neutralizing antibodies
(bNAbs) have revealed the critical role of trimeric context for immune recognition of HIV-1 …

The development of native-like HIV-1 envelope (Env) trimer antigens has enabled the
induction of neutralizing antibody (NAb) responses against neutralization-resistant HIV-1 …

The HIV-1 envelope glycoprotein trimer is poorly immunogenic because it is covered by a
dense glycan shield. As a result, recombinant Env glycoproteins generally elicit inadequate …

It is becoming increasingly clear that HIV-1 vaccine research might benefit greatly from using
nanoparticles presenting Env trimers, particularly during the priming stage of immunization …

Uncleaved prefusion-optimized (UFO) design can stabilize diverse HIV-1 envelope
glycoproteins (Envs). Single-component, self-assembling protein nanoparticles (1c-SApNP) …

A major step toward an HIV-1 vaccine is an immunogen capable of inducing neutralizing
antibodies. Envelope glycoprotein (Env) mimetics, such as the NFL and SOSIP designs …

Conformationally constrained peptidomimetics could be of great value in the design of
vaccines targeting protective epitopes on viral and bacterial pathogens. But the poor …

Inducing immune responses protecting from HIV infection or at least controlling replication
poses a huge challenge to modern vaccinology. An increasingly discussed strategy to elicit …