Gap junction-mediated cell-cell interactions are highly conserved and play essential roles in
cell survival, proliferation, differentiation and patterning. We report that Connexin 32 (Cx32) …

Background Bi-potential hepatic progenitor cells can give rise to both hepatocytes and
cholangiocytes, which is the last phase and critical juncture in terms of sequentially hepatic …

Liver cancer stem cells (LCSCs) are responsible for liver cancer recurrence, metastasis, and
drug resistance. Previous studies by the authors demonstrated that upregulated expression …

Elucidating the molecular mechanisms involved in the differentiation of stem cells to hepatic
cells is critical for both understanding normal developmental processes as well as for …

Gap junctional intercellular communication (GJIC) is important for maintaining the
pluripotency of mouse embryonic stem cells (mESC). However, human ESC (hESC) have a …

Gap junction intercellular communication (GJIC) plays an essential role in the control of
growth, differentiation, and functions of different tissues. The expression of connexins (Cxs) …

Since effective cell sourcing is a major challenge for the therapeutic management of liver
disease and liver failure, embryonic stem (ES) cells are being widely investigated as a …

The efficient generation of hepatocytes from human pluripotent stem cells (hPSCs) requires
the induction of a proper endoderm population, broadly characterized by the expression of …

Abstract Although the connexin32 (Cx32)‐mediated gap junction is abolished in
hepatocellular carcinoma (HCC), the expression of cytoplasmic Cx32 tends to increase in …

Connexin 32 (Cx32) is the main gap junction protein in hepatocytes and plays an important
role in the regulation of signal transfer and growth control in the liver by constructing gap …