Parkinson's disease is a recognisable clinical syndrome with a range of causes and clinical
presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; …

Parkinson's disease is a neurological disorder with evolving layers of complexity. It has long
been characterised by the classical motor features of parkinsonism associated with Lewy …

Parkinson's disease is the most common serious movement disorder in the world, affecting
about 1% of adults older than 60 years. The disease is attributed to selective loss of neurons …

Parkinson's disease is a movement disorder that mainly affects those of middle to old age. It
is progressive over many decades and is characterised by bradykinesia, resting tremor …

The clinical diagnosis of Parkinson's disease rests on the identification of the characteristics
related to dopamine deficiency that are a consequence of degeneration of the substantia …

Neurodegeneration in Parkinson's disease starts years before a clinical diagnosis can be
reliably made. The prediagnostic phase of the disease offers a window of opportunity in …

Over history, diseases have appeared and disappeared, or have increased or decreased in
frequency. These epidemiological trends have occurred more dramatically for infectious …

The causes of Parkinson's disease (PD), the second most common neurodegenerative
disorder, are still largely unknown. Current thinking is that major gene mutations cause only …

Debate is ongoing regarding when, why, and how to initiate pharmacotherapy for
Parkinson's disease. Early initiation of dopaminergic therapies does not convey disease …

Since 2006, several longitudinal studies have assessed environmental or behavioural
factors that seem to modify the risk of developing Parkinson's disease. Increased risk of …