Acute kidney injury (AKI) and chronic kidney disease (CKD) are worldwide public health
problems affecting millions of people and have rapidly increased in prevalence in recent …

Animal models are essential tools to understand the mechanisms underlying the
development and progression of renal disease and to study potential therapeutic …

While extensive research using animal models has improved the understanding of acute
kidney injury (AKI), this knowledge has not been translated into effective treatments. Many …

Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Chronic kidney diseases result from recurrent or progressive injuries in glomeruli, tubules,
interstitium and/or vasculature. To study pathogenesis, mechanisms and effects of …

Acute kidney injury (AKI) is an underestimated, yet important risk factor for development of
chronic kidney disease (CKD). Even after initial total recovery of renal function, some …

Animal models of chronic kidney disease (CKD) approximate the human condition and are
keys to understanding its pathogenesis and to developing rational treatment strategies. The …

Renal ischemia-reperfusion leads to acute kidney injury (AKI), a major kidney disease
associated with an increasing prevalence and high mortality rates. A variety of experimental …

Acute kidney injury (AKI) is a contributing factor in the development and progression of
chronic kidney disease (CKD). Despite rapid progresses, the mechanism underlying AKI …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are associated with decreased
renal function and increased mortality risk, while the therapeutic armamentarium is …