Altered glutamine metabolism is a hallmark of cancer growth, forming the theoretical basis
for development of metabolic therapies as cancer treatments. Glutaminase (GLS), a crucial …

Simple Summary High expression levels of glutaminase (GLS1) are reported for several
cancers, and correlate with parameters of disease status. GLS1, the rate-limiting enzyme in …

Cancer cells reprogram their metabolism towards aerobic glycolysis and elevated
glutaminolysis, which contributes to the aggressive phenotype. Understanding how these …

Glutamine metabolism is one of the hallmarks of cancers which is described as an essential
role in serving as a major energy and building blocks supply to cell proliferation in cancer …

Cellular metabolism in cancer is significantly altered to support the uncontrolled tumor
growth. How metabolic alterations contribute to hormonal therapy resistance and disease …

Background Glutaminase (GLS), the key enzyme that catalyzes glutamine catabolism,
facilitates the production of energy, building blocks, and factors resisting stresses. Two …

The targeting of glutamine metabolism specifically via pharmacological inhibition of
glutaminase 1 (GLS1) has been translated into clinical trials as a novel therapy for several …

Cancer cells remodel their metabolic programs towards aerobic glycolysis and elevated
glutaminolysis to meet the requirement s of rapid proliferation. Understanding how cells …

Cancer cells re-program their metabolic machinery to meet the requirements of malignant
transformation and progression. Glutaminase 1 (GLS1) was traditionally known as a …

Simple Summary Glutaminase GLS2 is an enzyme that metabolizes glutamine, one of the
main sources of energy and building blocks in tumor cells. In some types of cancer, this …