Despite significant advances in current understanding of mechanisms of pathogenesis in
Alzheimer's disease (AD), attempts at drug development based on those discoveries have …

Alzheimer's disease (AD) is the most common neurodegenerative disorder, resulting in the
progressive decline of cognitive function in patients. Familial forms of AD are tied to …

Protein tyrosine phosphatase 1B (PTP1B) is a typical member of the PTP family, considered
a direct negative regulator of several receptor and receptor-associated tyrosine kinases …

Protein tyrosine phosphatases (PTPs) are important regulator of neuronal signal
transduction and a growing number of PTPs have been implicated in Alzheimer's disease …

Protein phosphatase 2A (PP2A) is a large family of enzymes that account for the majority of
brain Ser/Thr phosphatase activity. While PP2A enzymes collectively modulate most cellular …

Protein phosphatase-2A (PP2A), an important phosphatase in dephosphorylating tau and
preserving synapse, is significantly suppressed in Alzheimer's disease (AD), but the …

Obesity and metabolic syndrome represent major public health problems, and are the
biggest preventable causes of death worldwide. Obesity is the leading risk factor for type 2 …

The protein tyrosine phosphatase PTP1B is a major regulator of glucose homeostasis and
energy metabolism, and a validated target for therapeutic intervention in diabetes and …

Protein tyrosine phosphatase 1B (PTP1B) emerged only 4 years ago as a new drug target
for the treatment of diabetes and, possibly, obesity. The enzyme belongs to the family of …

Background Protein tyrosine phosphatase 1B (PTP1B) is a member of the non-
transmembrane phosphotyrosine phosphatase family. Recently, PTP1B has been proposed …