Brain‐targeted aggregation‐induced‐emission nanoparticles with near‐infrared imaging at 1550 nm boosts orthotopic glioblastoma theranostics

J Wang, Y Liu, M Morsch, Y Lu… - Advanced …, 2022 - Wiley Online Library
A remaining challenge in the treatment of glioblastoma multiforme (GBM) is surmounting the
blood–brain barrier (BBB). Such a challenge prevents the development of efficient …

Scaffolds biomimicking macrophages for a glioblastoma NIR-Ib imaging guided photothermal therapeutic strategy by crossing Blood-Brain Barrier

J Lai, G Deng, Z Sun, X Peng, J Li, P Gong, P Zhang… - Biomaterials, 2019 - Elsevier
Glioblastoma (GBM) is one of the most malignant cancers, and Blood-Brain Barrier (BBB) is
the main obstacle to diagnose and treat GBM, hence scientists are making great efforts to …

Upregulating aggregation‐induced‐emission nanoparticles with blood–tumor‐barrier permeability for precise photothermal eradication of brain tumors and induction …

M Zhang, W Wang, M Mohammadniaei… - Advanced …, 2021 - Wiley Online Library
Compared to other tumors, glioblastoma (GBM) is extremely difficult to treat. Recently,
photothermal therapy (PTT) has demonstrated advanced therapeutic efficacy; however …

Identifying glioblastoma margins using dual-targeted organic nanoparticles for efficient in vivo fluorescence image-guided photothermal therapy

X Cai, A Bandla, CK Chuan, G Magarajah, LD Liao… - Materials …, 2019 - pubs.rsc.org
Current therapeutics for glioblastoma multiforme (GBM) treatment are unsatisfactory due to
their limited ability to control the progression from tumour margins. In this work, organic …

Starlike polymer brush-based ultrasmall nanoparticles with simultaneously improved NIR-II fluorescence and blood circulation for efficient orthotopic glioblastoma …

S Chen, H Miao, X Jiang, P Sun, Q Fan, W Huang - Biomaterials, 2021 - Elsevier
Fluorescence imaging (FI) in the second near-infrared region (NIR-II, 1000–1700 nm) has
attracted great attention for brain tumor imaging due to its deep penetration and high …

Engineering NIR-IIb fluorescence of Er-based lanthanide nanoparticles for through-skull targeted imaging and imaging-guided surgery of orthotopic glioma

F Ren, H Liu, H Zhang, Z Jiang, B Xia, C Genevois… - Nano Today, 2020 - Elsevier
Highly sensitive and specific discrimination of brain tumor margins from the surrounding
parenchyma remains a formidable challenge. Limited by the short of photostable probes …

Dual-Site Förster Resonance Energy Transfer Route of Upconversion Nanoparticles-Based Brain-Targeted Nanotheranostic Boosts the Near-Infrared Phototherapy …

J Wang, P Shangguan, M Lin, L Fu, Y Liu, L Han… - ACS …, 2023 - ACS Publications
Glioblastoma multiforme (GBM) is the most common malignant brain tumor with low survival,
primarily due to the blood–brain barrier (BBB) and high infiltration. Upconversion …

All-in-one theranostic platforms: deep-red AIE nanocrystals to target dual-organelles for efficient photodynamic therapy

R Xu, W Chi, Y Zhao, Y Tang, X Jing, Z Wang, Y Zhou… - ACS …, 2022 - ACS Publications
Aggregation-induced emission (AIE) nanoparticles have been widely applied in
photodynamic therapy (PDT) over the past few years. However, amorphous nanoaggregates …

Second near-infrared photodynamic therapy and chemotherapy of orthotopic malignant glioblastoma with ultra-small Cu 2− x Se nanoparticles

H Zhang, T Wang, H Liu, F Ren, W Qiu, Q Sun, F Yan… - Nanoscale, 2019 - pubs.rsc.org
The treatment of malignant glioblastoma is a huge challenge due to the existence of the
blood–brain barrier. Herein, we report the treatment of orthotopic malignant glioblastoma …

Upconversion nanoparticle-based cell membrane-coated cRGD peptide bioorthogonally labeled nanoplatform for glioblastoma treatment

J Mo, X Chen, M Li, W Liu, W Zhao, LY Lim… - … applied materials & …, 2022 - ACS Publications
Glioblastoma is hard to be eradicated partly because of the obstructive blood–brain barrier
(BBB) and the dynamic autophagy activities of glioblastoma. Here, hydroxychloroquine …