Cholesterol homeostasis is maintained through the coordinated regulation of the trafficking,
biosynthesis, absorption, and efflux of cholesterol. From the discovery that atherosclerotic …

First discovered as orphan receptors, liver X receptors (LXRs) were subsequently identified
as the nuclear receptor target of the cholesterol metabolites, oxysterols. There are 2 LXR …

Liver X receptors α (LXRα) and β (LXRβ) are essential for protection against cardiovascular
diseases. LXRs are members of the nuclear receptor superfamily of DNA-binding …

The liver X receptors (LXRα and LXRβ) are nuclear receptor transcription factors that are
activated by certain oxysterol derivatives of cholesterol. As such, LXR activity may be up …

Liver X receptors (LXRs) belong to the nuclear receptor superfamily of ligand-dependent
transcription factors. LXRs are activated by oxysterols, metabolites of cholesterol, and …

The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These
transcription factors control the expression of a battery of genes involved in the uptake …

Cellular cholesterol levels reflect a balance between uptake, efflux, and endogenous
synthesis. The sterol-responsive transcription factors liver X receptors (LXRα and LXRβ) …

The liver X receptors (LXRs) are nuclear receptors that play central roles in the
transcriptional control of lipid metabolism. LXRs function as nuclear cholesterol sensors that …

Liver X receptor (LXR) α and β are nuclear receptors that control cellular metabolism. LXRs
modulate the expression of genes involved in cholesterol and lipid metabolism in response …

Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the
transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in …