To further investigate new potent and selective human A1 adenosine receptor agonists, we
have synthesized a series of 5′-chloro-5′-deoxy-and 5′-(2-fluorophenylthio)-5′-deoxy …

A series of 5′-carbamoyl and 5′-thionocarbamoyl derivatives of 2′-C-methyl analogues
of the A1 adenosine receptor (A1AR) full agonists N6-cyclopentyladenosine (CPA), 2-chloro …

5 '-(Alkylthio)-substituted analogues of N 6-benzyl-and N 6-(3-iodobenzyl) adenosine were
synthesized in 37− 61% overall yields. The affinities of these compounds for the adenosine …

Our previous work discovered that combining the appropriate 5′-and N 6-substitution in
adenosine derivatives leads to the highly selective human A1 adenosine receptor (hA1AR) …

A series of 2-(N-acyl) and 2-(N-acyl)-N6-alkyladenosine analogues have been synthesized
from the intermediate 2-amino-6-chloroadenosine derivatives (2b and 7) and evaluated for …

Four subtypes of adenosine receptors are currently known, that is, A1, A2A, A2B, and A3
receptors. Interestingly, quite substantial species differences exist especially between …

Adenosines bearing 5′-modification in conjunction with an N6-substituent have previously
been shown to act as partial agonists at the A1 adenosine receptor. Our current work …

New N, 5 '-di-and N, 2, 5 '-trisubstituted adenosine derivatives were synthesized in good
overall yields. Appropriate 5-O-alkyl-substituted ribose moieties were coupled to 6 …

The affinity and efficacy at four subtypes (A1, A2A, A2B and A3) of human adenosine
receptors (ARs) of a wide range of 2-substituted adenosine derivatives were evaluated …

Novel 2, 8-disubstituted adenosine derivatives were synthesized in good overall yields
starting from 2-iodoadenosine. Binding affinities were determined for rat adenosine A1 and …