In this essay, we propose that embryos express a metabolic phenotype necessarily different
from that of differentiated somatic cells and more like that of rapidly proliferating cancer cells …

A key characteristic of cancer cells is the ability to switch from a predominantly oxidative
metabolism to glycolysis and the production of lactate even when oxygen is plentiful. This …

Glucose metabolism in preimplantation embryos has traditionally been viewed from a
somatic cell viewpoint. Here, we show that gene expression in early embryos is similar to …

Mammalian preimplantation embryos follow a stereotypic pattern of development from
zygotes to blastocysts. Here, we use labeled nutrient isotopologue analysis of small …

Although mammalian embryo development may be considered strictly to begin with the
formation of an oocyte, and progresses through implantation, organogenesis, and fetal …

Preimplantation embryonic development is associated with a change in preference in
energy metabolism pathways. Although oxidative phosphorylation is obligatory in most …

In vitro fertilization has provided a unique window into the metabolic processes that drive
embryonic growth and development from a fertilized ovum to a competent blastocyst. Post …

Decoding stem cell metabolism has implicated a tight linkage between energy metabolism
and cell fate regulation, a dynamic interplay vital in the execution of developmental and …

Mammalian embryogenesis relies on glycolysis and oxidative phosphorylation to balance
the generation of biomass with energy production. However, the dynamics of metabolic …

The preimplantation mammalian embryo offers many unique research opportunities. Among
these is the possibility of studying the progression of metabolic systems during the transition …