Mimicking the ice recrystallization activity of biological antifreezes. When is a new polymer “active”?

CI Biggs, C Stubbs, B Graham… - Macromolecular …, 2019 - Wiley Online Library
Antifreeze proteins and ice‐binding proteins have been discovered in a diverse range of
extremophiles and have the ability to modulate the growth and formation of ice crystals …

Slowing the growth of ice with synthetic macromolecules: beyond antifreeze (glyco) proteins

MI Gibson - Polymer Chemistry, 2010 - pubs.rsc.org
Biological antifreezes are a relatively large and diverse class of proteins (and very recently
expanded to include lipopolysaccharides) which are capable of interacting with ice crystals …

Inhibition of ice crystal growth by synthetic glycopolymers: implications for the rational design of antifreeze glycoprotein mimics

MI Gibson, CA Barker, SG Spain, L Albertin… - …, 2009 - ACS Publications
A series of structurally diverse polymers, containing either peptide or vinyl-derived
backbones, was tested for ice recrystallization inhibition activity, which is commonly …

Antifreeze (glyco) protein mimetic behavior of poly (vinyl alcohol): detailed structure ice recrystallization inhibition activity study

T Congdon, R Notman, MI Gibson - Biomacromolecules, 2013 - ACS Publications
This manuscript reports a detailed study on the ability of poly (vinyl alcohol) to act as a
biomimetic surrogate for antifreeze (glyco) proteins, with a focus on the specific property of …

Slow propagation of ice binding limits the ice-recrystallization inhibition efficiency of PVA and other flexible polymers

PM Naullage, V Molinero - Journal of the American Chemical …, 2020 - ACS Publications
Ice recrystallization inhibitors (IRI) are of critical importance in biology, cryopreservation of
cells and organs, and frozen foods. Antifreeze glycoproteins (AFGPs) are the most potent …

Ice recrystallisation inhibition by polyols: comparison of molecular and macromolecular inhibitors and role of hydrophobic units

RC Deller, T Congdon, MA Sahid, M Morgan… - Biomaterials …, 2013 - pubs.rsc.org
The ability of polyols to act as ice recrystallisation inhibitors (IRI), inspired by antifreeze
(glyco) proteins are studied. Poly (vinyl alcohol), PVA, a known IRI active polymer was …

Polymer mimics of biomacromolecular antifreezes

CI Biggs, TL Bailey, B Graham, C Stubbs… - Nature …, 2017 - nature.com
Antifreeze proteins from polar fish species are remarkable biomacromolecules which
prevent the growth of ice crystals. Ice crystal growth is a major problem in cell/tissue …

The importance of hydration for inhibiting ice recrystallization with C-linked antifreeze glycoproteins

P Czechura, RY Tam, E Dimitrijevic… - Journal of the …, 2008 - ACS Publications
The role of hydration in modulating solution conformation, molecular recognition, and
biological activity of oligosaccharides, proteins, and nucleotides is widely recognized but is …

Understanding poly (vinyl alcohol)-mediated ice recrystallization inhibition through ice adsorption measurement and pH effects

AA Burkey, CL Riley, LK Wang, TA Hatridge… - …, 2018 - ACS Publications
The development of improved cryopreservative materials is necessary to enable complete
recovery of living cells and tissue after frozen storage. Remarkably, poly (vinyl alcohol)(PVA) …

Designing ice recrystallization inhibitors: from antifreeze (glyco) proteins to small molecules

AK Balcerzak, CJ Capicciotti, JG Briard, RN Ben - RSC Advances, 2014 - pubs.rsc.org
Ice recrystallization occurs during cryopreservation and is correlated with reduced cell
viability after thawing. Therefore, ice recrystallization inhibition (IRI) activity is a very …