Mimicking the ice recrystallization activity of biological antifreezes. When is a new polymer “active”?
Antifreeze proteins and ice‐binding proteins have been discovered in a diverse range of
extremophiles and have the ability to modulate the growth and formation of ice crystals …
extremophiles and have the ability to modulate the growth and formation of ice crystals …
Slowing the growth of ice with synthetic macromolecules: beyond antifreeze (glyco) proteins
MI Gibson - Polymer Chemistry, 2010 - pubs.rsc.org
Biological antifreezes are a relatively large and diverse class of proteins (and very recently
expanded to include lipopolysaccharides) which are capable of interacting with ice crystals …
expanded to include lipopolysaccharides) which are capable of interacting with ice crystals …
Inhibition of ice crystal growth by synthetic glycopolymers: implications for the rational design of antifreeze glycoprotein mimics
A series of structurally diverse polymers, containing either peptide or vinyl-derived
backbones, was tested for ice recrystallization inhibition activity, which is commonly …
backbones, was tested for ice recrystallization inhibition activity, which is commonly …
Antifreeze (glyco) protein mimetic behavior of poly (vinyl alcohol): detailed structure ice recrystallization inhibition activity study
This manuscript reports a detailed study on the ability of poly (vinyl alcohol) to act as a
biomimetic surrogate for antifreeze (glyco) proteins, with a focus on the specific property of …
biomimetic surrogate for antifreeze (glyco) proteins, with a focus on the specific property of …
Slow propagation of ice binding limits the ice-recrystallization inhibition efficiency of PVA and other flexible polymers
PM Naullage, V Molinero - Journal of the American Chemical …, 2020 - ACS Publications
Ice recrystallization inhibitors (IRI) are of critical importance in biology, cryopreservation of
cells and organs, and frozen foods. Antifreeze glycoproteins (AFGPs) are the most potent …
cells and organs, and frozen foods. Antifreeze glycoproteins (AFGPs) are the most potent …
Ice recrystallisation inhibition by polyols: comparison of molecular and macromolecular inhibitors and role of hydrophobic units
RC Deller, T Congdon, MA Sahid, M Morgan… - Biomaterials …, 2013 - pubs.rsc.org
The ability of polyols to act as ice recrystallisation inhibitors (IRI), inspired by antifreeze
(glyco) proteins are studied. Poly (vinyl alcohol), PVA, a known IRI active polymer was …
(glyco) proteins are studied. Poly (vinyl alcohol), PVA, a known IRI active polymer was …
Polymer mimics of biomacromolecular antifreezes
Antifreeze proteins from polar fish species are remarkable biomacromolecules which
prevent the growth of ice crystals. Ice crystal growth is a major problem in cell/tissue …
prevent the growth of ice crystals. Ice crystal growth is a major problem in cell/tissue …
The importance of hydration for inhibiting ice recrystallization with C-linked antifreeze glycoproteins
P Czechura, RY Tam, E Dimitrijevic… - Journal of the …, 2008 - ACS Publications
The role of hydration in modulating solution conformation, molecular recognition, and
biological activity of oligosaccharides, proteins, and nucleotides is widely recognized but is …
biological activity of oligosaccharides, proteins, and nucleotides is widely recognized but is …
Understanding poly (vinyl alcohol)-mediated ice recrystallization inhibition through ice adsorption measurement and pH effects
The development of improved cryopreservative materials is necessary to enable complete
recovery of living cells and tissue after frozen storage. Remarkably, poly (vinyl alcohol)(PVA) …
recovery of living cells and tissue after frozen storage. Remarkably, poly (vinyl alcohol)(PVA) …
Designing ice recrystallization inhibitors: from antifreeze (glyco) proteins to small molecules
Ice recrystallization occurs during cryopreservation and is correlated with reduced cell
viability after thawing. Therefore, ice recrystallization inhibition (IRI) activity is a very …
viability after thawing. Therefore, ice recrystallization inhibition (IRI) activity is a very …