Exercise-induced hypoalgesia: potential mechanisms in animal models of neuropathic pain

K Kami, F Tajima, E Senba - Anatomical science international, 2017 - Springer
Physical exercise, such as forced treadmill running and swimming, can sufficiently improve
mechanical allodynia and heat hyperalgesia in animal models of neuropathic pain (NPP) …

[HTML][HTML] Histone acetylation in microglia contributes to exercise-induced hypoalgesia in neuropathic pain model mice

K Kami, S Taguchi, F Tajima, E Senba - The Journal of Pain, 2016 - Elsevier
Physical exercise can attenuate neuropathic pain (NPP), but the exact mechanism
underlying exercise-induced hypoalgesia (EIH) remains unclear. Recent studies have …

Plastic changes in amygdala subregions by voluntary running contribute to exercise-induced hypoalgesia in neuropathic pain model mice

K Kami, F Tajima, E Senba - Molecular Pain, 2020 - journals.sagepub.com
Physical exercise has been established as a low-cost, safe, and effective way to manage
chronic pain, but exact mechanisms underlying such exercise-induced hypoalgesia (EIH) …

Training-induced hypoalgesia and its potential underlying mechanisms

JS Song, Y Yamada, R Kataoka, V Wong… - Neuroscience & …, 2022 - Elsevier
It is well-established that a single bout of exercise can reduce pain sensitivity (ie, exercise-
induced hypoalgesia) in healthy individuals. However, exercise-induced hypoalgesia is …

[HTML][HTML] Exercise-induced hypoalgesia in pain-free and chronic pain populations: state of the art and future directions

D Rice, J Nijs, E Kosek, T Wideman, MI Hasenbring… - The Journal of …, 2019 - Elsevier
Exercise is considered an important component of effective chronic pain management and it
is well-established that long-term exercise training provides pain relief. In healthy, pain-free …

Brain mechanisms of exercise-induced hypoalgesia: to find a way out from “fear-avoidance belief”

K Kami, F Tajima, E Senba - International Journal of Molecular Sciences, 2022 - mdpi.com
It is well known that exercise produces analgesic effects (exercise-induced hypoalgesia
(EIH)) in animal models and chronic pain patients, but the brain mechanisms underlying …

Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids

NJ Stagg, HP Mata, MM Ibrahim… - The Journal of the …, 2011 - pubs.asahq.org
Background Exercise is often prescribed as a therapy for chronic pain. Short-term exercise
briefly increases the production of endogenous analgesics, leading to transient …

[HTML][HTML] Exercise-induced hypoalgesia after acute and regular exercise: experimental and clinical manifestations and possible mechanisms in individuals with and …

HB Vaegter, MD Jones - Pain reports, 2020 - journals.lww.com
Exercise and physical activity is recommended treatment for a wide range of chronic pain
conditions. In addition to several well-documented effects on physical and mental health, 8 …

Aerobic exercise attenuates pain sensitivity: an event-related potential study

K Zheng, C Chen, S Yang, X Wang - Frontiers in neuroscience, 2021 - frontiersin.org
In this study, electroencephalography (EEG) was utilized to explore the neurophysiological
mechanisms of aerobic exercise-induced hypoalgesia (EIH) and provide a theoretical basis …

[HTML][HTML] Endogenous systems involved in exercise-induced analgesia.

RDS Santos, G Galdino - JPP, 2018 - jpp.krakow.pl
Exercise-induced analgesia is a phenomenon discussed worldwide. This effect began to be
investigated in the early 1970s in healthy individuals and rodents during and after an acute …