Genes are not randomly distributed in the genome. In humans, 10% of protein‐coding genes
are transcribed from bidirectional promoters and many more are organised in larger clusters …

Background Gene order in eukaryotic genomes is not random. Genes showing similar
expression (coexpression) patterns are often clustered along the genome. The goal of this …

Gene expression is subject to stochastic noise, but to what extent and by which means such
stochastic variations are coordinated among different genes are unclear. We hypothesize …

Transcript co-expression is regulated by a combination of shared genetic and environmental
factors. Here, we estimate the proportion of co-expression that is due to shared genetic …

Steady-state levels of mRNA in cells theoretically depend on the rate and efficiency of
transcription and posttranscriptional processing, on mRNA stability, on transcriptional …

The spatial organization of eukaryotic genomes is thought to play an important role in
regulating gene expression. The recent advances in experimental methods including …

While it has been long recognized that genes are not randomly positioned along the
genome, the degree to which its 3D structure influences the arrangement of genes has …

The role of natural selection in biology is well appreciated. Recently, however, a critical role
for physical principles of network self-organization in biological systems has been revealed …

Variable gene expression within a clonal population of cells has been implicated in a
number of important processes including mutation and evolution,, determination of cell fates …

Gene order is not random with regard to gene expression in mammals: coexpressed genes,
and in particular housekeeping genes, are clustered along chromosomes more often than …