Sudden blastic transformation in treatment‐free remission chronic myeloid leukaemia.

M Alfayez, G Richard‐Carpentier… - British Journal of …, 2019 - search.ebscohost.com
This phase starts after discontinuation of TKI therapy, and is characterized by continued
remission with undetectable-or stable low detectable-disease by the most sensitive method …

Blastic transformation in chronic myelogenous leukemia: experience with 50 patients

SM Marks, R McCaffrey, DS Rosenthal… - Medical and …, 1978 - Wiley Online Library
Fifty consecutive patients with blastic chronic myelogenous leukemia were evaluated
clinically, morphologically, biochemically, and therapeutically. Forty‐five patients had a …

[引用][C] The blastic crisis of chronic myeloid leukaemia: acute transformation of a preleukaemic condition?

B Pedersen - British Journal of Haematology, 1973 - Wiley Online Library
The characteristic course of chronic niyeloid leukaemia (CML) includes a relatively long
phase where, after non-intensive treatment, the patients remain in a clinical and …

[引用][C] Current status of blastic transformation in chronic myelogenous leukemia

JC Barton, ME Conrad - American Journal of Hematology, 1978 - Wiley Online Library
Although chronic myelocytic leukemia (CML) represents only 15% of all cases of leukemia,
its maximal incidence occurs in the third to sixth decades of life such that individuals are …

The pathogenesis and clinical patterns of blastic crisis of chronic myeloid leukemia.

DR Boggs - Seminars in Oncology, 1976 - europepmc.org
Blast crisis terminates the life of the majority (approximately 80%) of patients with CML. The
time of its onset appears to be a random phenomenon, varying from a probable coincidence …

Relapse into blast crisis following bone marrow transplantation for chronic phase chronic myeloid leukaemia: a report of five cases

JO Cullis, DI Marks, AP Schwarer… - British journal of …, 1992 - Wiley Online Library
A proportion of patients receiving allogeneic bone marrow transplants (BMT) for chronic
myeloid leukaemia (CML) in first chronic phase relapse; most of these relapses show …

Sudden onset of the blastic phase of chronic myelogenous leukemia: Patterns and implications

H Kantarjian, S O'Brien, J Cortes, F Giles, D Thomas… - Cancer, 2003 - Wiley Online Library
BACKGROUND Therapeutic options in Philadelphia chromosome‐positive chronic
myelogenous leukemia (Ph‐positive CML) in chronic phase include allogeneic stem cell …

Molecular evidence for the clonal origin of blast crisis in chronic myeloid leukaemia

JR Zalcberg, ML Friedlander, MD Minden - British journal of cancer, 1986 - nature.com
Cytogenetic and enzymatic studies have shown that chronic myeloid leukemia (CML)
represents the clonal proliferation of a pluripotent stem cell. The Philadelphia chromosome …

Factors affecting duration of survival after onset of blastic transformation of chronic myeloid leukemia

J Wadhwa, RM Szydlo, JF Apperley… - Blood, The Journal …, 2002 - ashpublications.org
We analyzed factors having an impact on response to treatment and survival in 78
consecutive patients with chronic myeloid leukemia (CML) in blastic transformation (BT) …

Treatment free remission in chronic myeloid leukemia: Lights and shadows

M Molica, NI Noguera, MM Trawinska, G Martinelli… - Hematology …, 2020 - mdpi.com
In addition to the best possible overall survival, discontinuation of the tyrosine kinase-
inhibitor (TKI) treatment [treatment free remission (TFR)] without observing a recurrence of …