Positron emission tomography (PET) is a molecular imaging modality that enables non-
invasive visualization of tracer distribution and pharmacology. Recently, peptides with long …

Positron emission tomography (PET) imaging is used in drug development to noninvasively
measure biodistribution and receptor occupancy. Ideally, PET tracers retain target binding …

Introduction Lately, zirconium-89 has shown great promise as a radionuclide for PET
applications of long circulating biomolecules. Here, the design and synthesis of protracted …

The glucagonlike peptide-1 receptor (GLP1R) is a gut hormone receptor, intricately linked to
regulation of blood glucose homeostasis via several mechanisms. It is an established and …

The glucagon receptor (GCGR) is emerging as an important target in anti-diabetic therapy,
especially as part of the pharmacology of dual glucagon-like peptide-1/glucagon (GLP …

Background Several radiometal-labeled, exendin-based tracers that target glucagon-like
peptide-1 receptors (GLP-1R) have been intensively explored for β cell imaging. The main …

Abstract Purpose Copper-64 (Cu-64) and Galium-68 (Ga-68) radiolabeled DO3A and NODA
conjugates of exendin-4 were used for preclinical imaging of pancreatic β cells via targeting …

The glucagonlike peptide 1 receptor (GLP-1R) is mainly expressed on β-cells in the islets of
Langerhans and is therefore an attractive target for imaging of the β-cell mass. In the present …

Control of the biodistribution of radiolabeled peptides has proven to be a major challenge in
their application as imaging agents for positron emission tomography (PET). Modification of …

The glucagon receptor (GCGR) is an emerging target in anti-diabetic therapy. Reliable
biomarkers for in vivo activity on the GCGR, in the setting of dual glucagon-like peptide …