Distinct CD8 T cell populations with differential exhaustion profiles associate with secondary complications in common variable immunodeficiency
A Klocperk, D Friedmann, AE Schlaak, S Unger… - Journal of Clinical …, 2022 - Springer
Purpose Common variable immunodeficiency (CVID) is the most frequent symptomatic
primary immunodeficiency, with heterogeneous clinical presentation. Our goal was to …
primary immunodeficiency, with heterogeneous clinical presentation. Our goal was to …
[HTML][HTML] In-depth immune profiling reveals advanced B-and T-cell differentiation to be associated with Th1-driven immune dysregulation in common variable …
J Hultberg, E Blixt, R Göransson, J Adolfsson… - Clinical …, 2023 - Elsevier
Common variable immunodeficiency (CVID) is an inborn error of immunity characterized by
low levels of antibodies. In addition to infections, many patients also suffer from T-helper 1 …
low levels of antibodies. In addition to infections, many patients also suffer from T-helper 1 …
Chronically activated T-cells retain their inflammatory properties in common variable immunodeficiency
RM Berbers, MM van der Wal, JM van Montfrans… - Journal of Clinical …, 2021 - Springer
Purpose Immune dysregulation complications cause significant morbidity and mortality in
common variable immunodeficiency (CVID), but the underlying pathophysiology is poorly …
common variable immunodeficiency (CVID), but the underlying pathophysiology is poorly …
T cell phenotypes in patients with common variable immunodeficiency disorders: associations with clinical phenotypes in comparison with other groups with recurrent …
Common variable immunodeficiency disorders (CVID) are a group of heterogeneous
conditions that have in common primary failure of B cell function, although numerous T cell …
conditions that have in common primary failure of B cell function, although numerous T cell …
Unravelling the complexity of T cell abnormalities in common variable immunodeficiency
A Giovannetti, M Pierdominici, F Mazzetta… - The Journal of …, 2007 - journals.aai.org
We investigated several phenotypic and functional parameters of T cell-mediated immunity
in a large series of common variable immunodeficiency (CVID) patients. We demonstrated …
in a large series of common variable immunodeficiency (CVID) patients. We demonstrated …
Comparison of various classifications for patients with common variable immunodeficiency (CVID) using measurement of B-cell subsets
R Yazdani, R Seify, M Ganjalikhani-Hakemi… - Allergologia et …, 2017 - Elsevier
Background Common variable immunodeficiency (CVID) is a heterogeneous disease,
characterised by hypogammaglobulinaemia leading to recurrent infections and various …
characterised by hypogammaglobulinaemia leading to recurrent infections and various …
The TH1 phenotype of follicular helper T cells indicates an IFN-γ–associated immune dysregulation in patients with CD21low common variable immunodeficiency
S Unger, M Seidl, P van Schouwenburg… - Journal of allergy and …, 2018 - Elsevier
Background A subgroup of patients with common variable immunodeficiency (CVID)
experience immune dysregulation manifesting as autoimmunity, lymphoproliferation, and …
experience immune dysregulation manifesting as autoimmunity, lymphoproliferation, and …
Low percentages of regulatory T cells in common variable immunodeficiency (CVID) patients with autoimmune diseases and its association with increased numbers of …
G López-Herrera, NH Segura-Méndez… - Allergologia et …, 2019 - Elsevier
Background Common variable immunodeficiency (CVID) is a heterogeneous group of
primary antibody deficiencies defined by marked reductions in serum IgG, IgA and/or IgM …
primary antibody deficiencies defined by marked reductions in serum IgG, IgA and/or IgM …
Altered fraction of regulatory B and T cells is correlated with autoimmune phenomena and splenomegaly in patients with CVID
E Kofod-Olsen, SE Jørgensen, SK Nissen, L Westh… - Clinical …, 2016 - Elsevier
Common variable immunodeficiency (CVID) is a heterogeneous primary immunodeficiency
disease, leading to recurrent bacterial airway infections and often also autoimmune …
disease, leading to recurrent bacterial airway infections and often also autoimmune …
Immunophenotypic profile of T cells in common variable immunodeficiency: is there an association with different clinical findings?
N Lanio, E Sarmiento, A Gallego, J Carbone - Allergologia et …, 2009 - Elsevier
BACKGROUND: A system based on the B-cell phenotype has recently been proposed to
classify patients suffering from common variable immunodeficiency (CVID) …
classify patients suffering from common variable immunodeficiency (CVID) …