The decline of oxygen tension in the tissues below the physiological demand leads to the
hypoxic adaptive response. This physiological consequence enables cells to recover from …

Abstract Hypoxia-inducible factors (HIFs) 1 and 2 are dimeric α/β transcription factors that
regulate cellular responses to low oxygen. HIF-1 is induced first, whereas HIF-2 is …

Adaptive changes to oxygen availability are critical for cell survival and tissue homeostasis.
Prolonged oxygen deprivation due to reduced blood flow to cardiac or peripheral tissues …

Hypoxia-inducible factors (HIF) are heterodimeric transcription factors that allow cells to
adapt and survive during hypoxia. Regulation of HIF1A and HIF2A mRNA is well …

Adaptation to hypoxia is an essential cellular response controlled by the oxygen-sensitive
master transcription factor hypoxia-inducible factor 1 (HIF-1). HIF-1 expression is also …

During hypoxia, a cellular adaptive response activates hypoxia-inducible factors (HIFs; HIF-
1 and HIF-2) that respond to low tissue-oxygen levels and induce the expression of a …

Effective vascular regeneration could provide therapeutic benefit for multiple pathologies,
especially in chronic peripheral artery disease (PAD) and myocardial ischemia. The hypoxia …

The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism.
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular …

Hypoxia is a state where oxygen availability/delivery is below the level necessary to
maintain physiological oxygen tension for a particular tissue. It is well-established that when …

The hypoxia-inducible factor (HIF) is a key regulator of the transcriptional response to
hypoxia. While the mechanism underpinning HIF activation is well understood, little is known …