Objectives The HIV-1 genetic diversity and the presence of transmitted drug resistance
mutations (TDRMs) against integrase strand transfer inhibitors (INSTIs) were assessed …

Background Transmission of resistance mutations to integrase strand transfer inhibitors
(INSTIs) in HIV-infected patients may compromise the efficacy of first-line antiretroviral …

Objectives This study evaluated the emergence of mutations associated with integrase
strand transfer inhibitors (INSTI) resistance (INSTI-RMs) and the integrase evolution in …

The World Health Organization (WHO) has put forth recommendations for the use of
integrase (IN) strand transfer inhibitors (INSTIs) to be part of the first-line combination …

The latest class of antiretrovirals (ARVs), including integrase strand transfer inhibitors
(INSTIs), has been demonstrated to be effective for antiretroviral therapy (ART). Despite all …

Background: Antiretroviral drugs targeting integrase (IN) have recently been approved for
use in combined and salvage therapeutic interventions. Objective: To evaluate the presence …

Objectives To determine natural phenotypic susceptibility of non-group M HIV-1 to integrase
strand transfer inhibitors (INSTIs) in a large panel of 39 clinical strains from groups O, N and …

Integrase strand transfer inhibitor (InSTI) resistance rates are low. However, genotypic
resistance test (GRT) is not routinely performed in many centers. The aim of this study is to …

Objectives The objective of this study was to define the natural genotypic variation of the HIV-
1 integrase gene across Europe for epidemiological surveillance of integrase strand-transfer …

Objective The integrase strand-transfer inhibitors (INSTIs) are an important class in the
arsenal of antiretroviral drugs designed to block the integration of HIV-1 cDNA into the host …