Immunological regulatory effect of flavonoid baicalin on innate immune toll-like receptors

M Jiang, Z Li, G Zhu - Pharmacological research, 2020 - Elsevier
As an essential component of the innate immune system, Toll-like receptors (TLRs) are a
family of well-recognized ligand-binding receptors found in various organisms and initiate …

Role of TLR4 and TCR or BCR against baicalin-induced responses in T and B cells

SQ Gong, W Sun, M Wang, YY Fu - International Immunopharmacology, 2011 - Elsevier
Baicalin (BA), a flavonoid compound isolated from Scutellaria baicalensis, has been shown
to possess a number of pharmacological effects including antiviral, anti-inflammatory …

Baicalin from Scutellaria baicalensis impairs Th1 polarization through inhibition of dendritic cell maturation

ME Kim, HK Kim, HY Park, DH Kim… - Journal of …, 2013 - jstage.jst.go.jp
Baicalin from Scutellaria baicalensis is a major flavonoid constituent found in the traditional
Chinese medicinal herb Baikal skull cap. It has been widely used for the treatment of various …

Baicalin inhibits lipopolysaccharide-induced inflammation through signaling NF-κB pathway in HBE16 airway epithelial cells

S Dong, Y Zhong, W Lu, G Li, H Jiang, B Mao - Inflammation, 2015 - Springer
Baicalin, a flavonoid monomer derived from Scutellaria baicalensis called Huangqin in
mandarin, is the main active ingredient contributing to S. baicalensis' efficacy. It is known in …

Isobavachalcone suppresses expression of inducible nitric oxide synthase induced by Toll-like receptor agonists

HJ Shin, DH Shon, HS Youn - International Immunopharmacology, 2013 - Elsevier
Toll-like receptors (TLRs) play an important role by recognizing many pathogen-associated
molecular patterns and inducing innate immunity. Dysregulated activation of TLR signaling …

The effects of baicalin on the TLR2/4 signaling pathway in the peripheral blood mononuclear cells of a lipopolysaccharide-induced rat fever model

L Ye, Y Tao, Y Wang, T Feng, H Li - International Immunopharmacology, 2015 - Elsevier
Baicalin, which is a flavonoid compound isolated from Scutellariae radix, has significant
antipyretic effects. The aim of the present study was to evaluate the effects of baicalin on the …

Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway

LT Guo, SQ Wang, J Su, LX Xu, ZY Ji, RY Zhang… - Journal of …, 2019 - Springer
Background Baicalin, which is isolated from Radix Scutellariae, possesses strong biological
activities including an anti-inflammation property. Recent studies have shown that the anti …

Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules

EH Kim, B Shim, S Kang, G Jeong, J Lee, YB Yu… - Journal of …, 2009 - Elsevier
AIM OF THE STUDY: A herbal preparation using Scutellaria baicalensis (S. baicalensis)
Georgi (Huang Qin, SB) was formulated to effectively protect cancer patients from …

Differential regulation of MyD88-and TRIF-dependent signaling pathways of Toll-like receptors by cardamonin

AY Kim, HJ Shim, SY Kim, S Heo, HS Youn - International …, 2018 - Elsevier
Toll-like receptors (TLRs) play a crucial role in the induction of innate immune response
against bacterial and viral infections. TLRs induce downstream signaling via MyD88-and …

Novel isoquinoline alkaloid Litcubanine Aa potential anti-inflammatory candidate

H Xia, Y Liu, G Xia, Y Liu, S Lin, L Guo - Frontiers in Immunology, 2021 - frontiersin.org
Macrophages play a critical role in innate and adaptive immunity, and the regulation of
macrophage function in inflammatory disease treatment has been widely studied. Litsea …