Retinoic acid (RA) directs the sequential, but distinct, programs of spermatogonial
differentiation and meiotic differentiation that are both essential for the generation of …

Direct evidence for a role of endogenous retinoic acid (RA), the active metabolite of vitamin
A in the initial differentiation and meiotic entry of spermatogonia, and thus in the initiation of …

Retinoic acid (RA), the active metabolite of vitamin A, is known to be required for the
differentiation of spermatogonia. The first round of spermatogenesis initiates in response to …

Throughout the reproductive lifespan of most male mammals, sperm production is constant
because of the regulated differentiation of spermatogonia. Retinoic acid (RA) and a …

Retinoic acid (RA) is the proposed mammalian 'meiosis inducing substance'. However,
evidence for this role comes from studies in the fetal ovary, where germ cell differentiation …

Mammalian spermatogenesis is an elaborately organized differentiation process, starting
with diploid spermatogonia, which include germ-line stem cells, and ending with haploid …

Retinoic acid (RA) signaling is crucial for spermatogonial differentiation, which is a key step
for spermatogenesis. We explored the mechanisms underlying spermatogonial …

Male fertility depends on the regulatory balance between germ cell self-renewal and
differentiation, and the spatial and temporal patterns of this balance must be maintained …

In the mammalian testis, sustained spermatogenesis relies on spermatogonial stem cells
(SSCs); their progeny either remain as stem cells (self-renewal) or proliferate and …

In mammals, most neonatal male germ cells (prospermatogonia) are quiescent and located
in the center of the testis cords. In response to an unknown signal, prospermatogonia …