Emerging roles of the neuronal nucleolus

M Hetman, M Pietrzak - Trends in neurosciences, 2012 - cell.com
Although, the nucleolus has been observed for almost 200 years in neurons, studies that
directly address the neuronal roles of this subnuclear structure have appeared only recently …

New roles for the nucleolus in health and disease

L Núñez Villacís, MS Wong, LL Ferguson, N Hein… - …, 2018 - Wiley Online Library
Over the last decade, our appreciation of the importance of the nucleolus for cellular function
has progressed from the ordinary to the extraordinary. We no longer think of the nucleolus …

[HTML][HTML] Therapeutic approaches targeting nucleolus in cancer

P Carotenuto, A Pecoraro, G Palma, G Russo, A Russo - Cells, 2019 - mdpi.com
The nucleolus is a distinct sub-cellular compartment structure in the nucleus. First observed
more than 200 years ago, the nucleolus is detectable by microscopy in eukaryotic cells and …

[HTML][HTML] Nucleolar function in lifespan regulation

V Tiku, A Antebi - Trends in cell biology, 2018 - cell.com
The nucleolus is a prominent membraneless organelle residing within the nucleus. The
nucleolus has been regarded as a housekeeping structure mainly known for its role in …

The multifunctional nucleolus

FM Boisvert, S Van Koningsbruggen… - … reviews Molecular cell …, 2007 - nature.com
The nucleolus is a distinct subnuclear compartment that was first observed more than 200
years ago. Nucleoli assemble around the tandemly repeated ribosomal DNA gene clusters …

[HTML][HTML] Nucleolar activity in neurodegenerative diseases: a missing piece of the puzzle?

R Parlato, G Kreiner - Journal of Molecular Medicine, 2013 - Springer
Nucleoli are the sites where synthesis of rRNA and ribosomal assembly take place. Along
with these “traditional” roles, the nucleolus controls cellular physiology and homeostasis …

[HTML][HTML] The nucleolus: a central response hub for the stressors that drive cancer progression

SE Weeks, BJ Metge, RS Samant - Cellular and Molecular Life Sciences, 2019 - Springer
The nucleolus is a sub-nuclear body known primarily for its role in ribosome biogenesis.
Increased number and/or size of nucleoli have historically been used by pathologists as a …

[HTML][HTML] Nucleolus: the fascinating nuclear body

V Sirri, S Urcuqui-Inchima, P Roussel… - Histochemistry and cell …, 2008 - Springer
Nucleoli are the prominent contrasted structures of the cell nucleus. In the nucleolus,
ribosomal RNAs are synthesized, processed and assembled with ribosomal proteins. RNA …

[HTML][HTML] The nucleolus: reviewing oldies to have new understandings

SJ Lo, CC Lee, HJ Lai - Cell research, 2006 - nature.com
The nucleolus is the most prominent compartment in the nucleus and known as the site for
ribosome biogenesis in eucaryotes. In contrast, there is no such equivalent structure for …

[HTML][HTML] Nucleolar organization and functions in health and disease

U Stochaj, SC Weber - Cells, 2020 - mdpi.com
The nucleolus is a prominent, membraneless compartment found within the nucleus of
eukaryotic cells. It forms around ribosomal RNA (rRNA) genes, where it coordinates the …