Targeted sequencing in DLBCL, molecular subtypes, and outcomes: a Haematological Malignancy Research Network report

SE Lacy, SL Barrans, PA Beer, D Painter… - Blood, The Journal …, 2020 - ashpublications.org
Based on the profile of genetic alterations occurring in tumor samples from selected diffuse
large B-cell lymphoma (DLBCL) patients, 2 recent whole-exome sequencing studies …

Array comparative genomic hybridization reveals genomic copy number changes associated with outcome in diffuse large B-cell lymphomas

W Chen, J Houldsworth, AB Olshen, G Nanjangud… - Blood, 2006 - ashpublications.org
To identify, in high-resolution regions of DNA, the copy number changes associated with
outcome in patients with diffuse large B-cell lymphoma (DLBCL), a disease with an …

Genetic profiling of MYC and BCL2 in diffuse large B-cell lymphoma determines cell-of-origin–specific clinical impact

D Ennishi, A Mottok, S Ben-Neriah… - Blood, The Journal …, 2017 - ashpublications.org
The clinical significance of MYC and BCL2 genetic alterations in diffuse large B-cell
lymphoma (DLBCL), apart from translocations, has not been comprehensively investigated …

Diffuse large B-cell lymphoma genotyping on the liquid biopsy

D Rossi, F Diop, E Spaccarotella… - Blood, The Journal …, 2017 - ashpublications.org
Accessible and real-time genotyping for diagnostic, prognostic, or treatment purposes is
increasingly impelling in diffuse large B-cell lymphoma (DLBCL). Cell-free DNA (cfDNA) is …

Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA

F Scherer, DM Kurtz, AM Newman, H Stehr… - Science translational …, 2016 - science.org
Patients with diffuse large B cell lymphoma (DLBCL) exhibit marked diversity in tumor
behavior and outcomes, yet the identification of poor-risk groups remains challenging. In …

Genetics and pathogenesis of diffuse large B-cell lymphoma

R Schmitz, GW Wright, DW Huang… - New England journal …, 2018 - Mass Medical Soc
Background Diffuse large B-cell lymphomas (DLBCLs) are phenotypically and genetically
heterogeneous. Gene-expression profiling has identified subgroups of DLBCL (activated B …

[HTML][HTML] MYD88 mutations identify a molecular subgroup of diffuse large B-cell lymphoma with an unfavorable prognosis

JS Vermaat, SF Somers, LC de Wreede, W Kraan… - …, 2020 - ncbi.nlm.nih.gov
Abstract The 2016 World Health Organization classification defines diffuse large B-cell
lymphoma (DLBCL) subtypes based on Epstein-Barr virus (EBV) infection and oncogenic …

[HTML][HTML] A probabilistic classification tool for genetic subtypes of diffuse large B cell lymphoma with therapeutic implications

GW Wright, JD Phelan, ZA Coulibaly, S Roulland… - Cancer cell, 2020 - cell.com
The development of precision medicine approaches for diffuse large B cell lymphoma
(DLBCL) is confounded by its pronounced genetic, phenotypic, and clinical heterogeneity …

Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing

RD Morin, K Mungall, E Pleasance… - Blood, The Journal …, 2013 - ashpublications.org
Diffuse large B-cell lymphoma (DLBCL) is a genetically heterogeneous cancer composed of
at least 2 molecular subtypes that differ in gene expression and distribution of mutations …

DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma

R Shaknovich, H Geng, NA Johnson… - Blood, The Journal …, 2010 - ashpublications.org
Expression profiling has shown 2 main and clinically distinct subtypes of diffuse large B-cell
lymphomas (DLBCLs): germinal-center B cell–like (GCB) and activated B cell–like (ABC) …