Genome-wide association studies (GWASs) have reproducibly associated variants within
intergenic regions of 1p36. 12 locus with osteoporosis, but the functional roles underlying …

INTRODUCTION: Chromosome 1p36 is a region that has previously shown good evidence
of linkage to bone mineral density (BMD) in multiple studies, but the genes that are …

Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons.
Genome-wide association studies (GWAS) have become an unbiased approach to identify …

Previous genome-wide linkage and association studies have identified an osteoporosis-
associated locus at 1p36 that harbors SNPs rs34920465 and rs6426749. The 1p36 locus …

Osteoporotic fracture (OF) is a serious outcome of osteoporosis. Important risk factors for OF
include reduced bone mineral density and unstable bone structure. This genome-wide copy …

Osteoporosis is characterized by increased bone loss and deterioration of bone
microarchitecture, which will lead to reduced bone strength and increased risk of fragility …

In the present study, aiming to identify loci associated with osteoporosis, we conducted a
joint association study of 2 independent genome-wide association meta-analyses of femoral …

Osteoporosis in premenopausal women with intact gonadal function and no known
secondary cause of bone loss is termed idiopathic osteoporosis (IOP). Women with IOP …

ABSTRACT RANKL is a key regulator involved in bone metabolism, and a drug target for
osteoporosis. The clinical diagnosis and assessment of osteoporosis are mainly based on …

Background Osteoporosis is a complex disease with a strong genetic contribution. A recently
published genome-wide association study (GWAS) for estimated bone mineral density …