Application of “click” chemistry in biomedical hydrogels

X Li, Y Xiong - ACS omega, 2022 - ACS Publications
Since “click” chemistry was first reported in 2001, it has remained a popular research topic in
the field of chemistry due to its high yield without byproducts, fast reaction rate, simple …

Fabrication and functionalization of hydrogels through “click” chemistry

S Yigit, R Sanyal, A Sanyal - Chemistry–An Asian Journal, 2011 - Wiley Online Library
Hydrogels are crosslinked polymeric materials that play a vital role in many biomedical
areas such as drug delivery, sensor technology, and tissue engineering. Increasing demand …

Click Chemistry and Material Selection for in Situ Fabrication of Hydrogels in Tissue Engineering Applications

Z Xu, KM Bratlie - ACS Biomaterials Science & Engineering, 2018 - ACS Publications
This Review gives a brief introduction to hydrogels formed through click chemistry for
applications in tissue engineering. Specifically, we focus on three representative click …

Covalently Crosslinked hydrogels via step‐growth reactions: crosslinking chemistries, polymers, and clinical impact

Y Gao, K Peng, S Mitragotri - Advanced Materials, 2021 - Wiley Online Library
Hydrogels are an important class of biomaterials with the unique property of high‐water
content in a crosslinked polymer network. In particular, chemically crosslinked hydrogels …

Click chemistry-based biopolymeric hydrogels for regenerative medicine

Y Li, X Wang, Y Han, HY Sun, J Hilborn… - Biomedical …, 2021 - iopscience.iop.org
Click chemistry is not a single specific reaction, but describes ways of generating products
which emulate examples in nature. Click reactions occur in one pot, are not disturbed by …

Translational applications of hydrogels

S Correa, AK Grosskopf, H Lopez Hernandez… - Chemical …, 2021 - ACS Publications
Advances in hydrogel technology have unlocked unique and valuable capabilities that are
being applied to a diverse set of translational applications. Hydrogels perform functions …

Click chemistry in biomaterials, nanomedicine, and drug delivery

KS Anseth, HA Klok - Biomacromolecules, 2016 - ACS Publications
The term “click chemistry” is generally used to describe reactions that are quick, highly
selective, versatile, and high yielding when connecting two molecular components. 1, 2 …

Recent advances in bio-orthogonal and dynamic crosslinking of biomimetic hydrogels

MR Arkenberg, HD Nguyen, CC Lin - Journal of Materials Chemistry B, 2020 - pubs.rsc.org
In recent years, dynamic,'click'hydrogels have been applied in numerous biomedical
applications. Owing to the mild, cytocompatible, and highly specific reaction kinetics, a …

Designing injectable, covalently cross‐linked hydrogels for biomedical applications

M Patenaude, NMB Smeets… - Macromolecular rapid …, 2014 - Wiley Online Library
Hydrogels that can form spontaneously via covalent bond formation upon injection in vivo
have recently attracted significant attention for their potential to address a variety of …

Enzymatic crosslinked hydrogels for biomedical application

E Badali, M Hosseini, M Mohajer… - … science, series A, 2021 - Springer
Self-assembled structures primarily arise through enzyme-regulated phenomena in nature
under persistent conditions. Enzymatic reactions are one of the main biological processes …